PMID: 8943171Jan 1, 1997Paper

Iodide or L-thyroxine to prevent recurrent goiter in an iodine-deficient area: prospective sonographic study

World Journal of Surgery
J FeldkampH D Röher

Abstract

In a randomized study, prevention of goiter recurrence with L-thyroxine was compared with pure iodide substitution after thyroid surgery for nodular goiter in an iodine-deficient area. Altogether 107 patients were followed up for 52 weeks after thyroid resection. The thyroid volume was determined sonographically. Free thyroxine, total thyroxine, thyrotropin, thyroglobulin, and antibodies to thyroglobulin and thyroid peroxidase were measured. The thyroid volume decreased slightly over the course of a year in the two therapy groups. There was no significant difference between the two groups. Recurrences were seen with both L-thyroxine medication and iodide substitution. The thyroglobulin levels fell significantly over the 52-week follow-up period in the iodide group. Antibody formation was not observed under iodine substitution. In an area of iodine deficiency, substitution with iodide is just as effective as medicating the patients with L-thyroxine for preventing recurrences.

Citations

Jan 20, 2006·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·S SaalabianR A Wahl
Mar 4, 2008·World Journal of Surgery·Roy Phitayakorn, Christopher R McHenry
Oct 28, 2008·The Journal of Surgical Research·Roy PhitayakornChristopher R McHenry
Feb 18, 2003·Endocrine Reviews·Laszlo HegedüsFinn N Bennedbaek

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