Iodide suppression of major histocompatibility class I gene expression in thyroid cells involves enhancer A and the transcription factor NF-kappa B

Molecular Endocrinology
S I TaniguchiL D Kohn

Abstract

High concentrations of iodide can induce transient, clinical improvement in patients with autoimmune Graves' disease. Previous work has related this iodide action to the autoregulatory effect of iodide on the growth and function of the thyroid; more recently, we additionally related this to the ability of iodide to suppress major histocompatibility (MHC) class I RNA levels and antigen expression on thyrocytes. In this report, we describe a transcriptional mechanism involved in iodide suppression of class I gene expression, which is potentially relevant to the autoregulatory action of iodide. Transfection experiments in FRTL-5 cells show that iodide decreases class I promoter activity and that this effect can be ascribed to the ability of iodide to modulate the formation of two specific protein/DNA complexes with enhancer A, -180 to -170 bp, of the class 1 5'-flanking region. Thus, iodide decreases the formation of Mod-1, an enhancer A complex involving the p50 subunit of NF-kappa B and a c-fos family member, fra-2, which was previously shown to be important in the suppression of class I levels by hydrocortisone. Unlike hydrocortisone, iodide also increases the formation of a complex with enhancer A, which we show, in antibody s...Continue Reading

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Citations

Mar 6, 2002·Clinical and Experimental Immunology·K SuzukiL D Kohn
Dec 12, 2012·Clinical Endocrinology·Shoichiro IzawaShin-ichi Taniguchi
Dec 29, 2000·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·A V Kudrin
Dec 29, 2000·International Reviews of Immunology·L D KohnM Saji
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Sep 7, 2018·Frontiers in Endocrinology·Cesidio GiulianiGiorgio Napolitano
Feb 6, 2010·Biochemical and Biophysical Research Communications·Koichi SuzukiLeonard D Kohn

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