PMID: 9420702Mar 1, 1994Paper

Iodine 123-labeled metaiodobenzylguanidine imaging in heart disease

Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology
P MerletA Syrota

Abstract

Scintigraphic images of myocardial iodine 123-labeled metaiodobenzylguanidine (MIBG) reflect the relative distribution of adrenergic neurodensity and function in the myocardium. In patients with hypertrophic cardiomyopathy or after infarction, MIBG uptake in hypertrophied myocardium and the infarct-related myocardium was found to be decreased in comparison to blood flow distribution, delineated with thallium 201. Most intriguingly, semiquantitative measurements in patients with congestive heart failure demonstrated reduced myocardial MIBG uptake. This reduction correlated directly with indexes of left ventricular function. Decreases in neuronal density, dysfunction of adrenergic neurons, or chronically elevated circulating norepinephrine levels may account for this diminished myocardial uptake, which, as demonstrated in a pilot study of 90 patients with congestive heart failure, was found to be of predictive value for survival.

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Citations

Jul 1, 2006·European Journal of Nuclear Medicine and Molecular Imaging·Maureen M HennemanJeroen J Bax
Nov 13, 2001·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·S MiyagawaH Matsuda
Dec 1, 1996·International Journal of Cardiac Imaging·G A SomsenE A van Royen
May 30, 2017·Rinshō shinkeigaku = Clinical neurology·Satoshi Orimo
Sep 17, 2008·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Claudia KusmicGianmario Sambuceti

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