PMID: 9247507Aug 1, 1997Paper

Iodine-123 metaiodobenzylguanidine cardiac imaging to identify and localize vasospastic angina without significant coronary artery narrowing

Journal of the American College of Cardiology
K SakataC Kurata

Abstract

We assessed the ability of iodine-123 metaiodobenzylguanidine (MIBG) imaging to identify and localize coronary spasm and determined the most useful method of MIBG analysis in vasospastic angina without significant coronary narrowing. Various noninvasive methods have been used to detect vasospastic angina, but they are not very sensitive in patients with sporadic attacks. MIBG imaging has recently been proposed as a useful tool for detecting vasospastic angina. Normal limits of both visual and quantitative analysis of two-dimensional polar maps (bull's-eyes) for MIBG imaging were at first established in 59 normal subjects. For optimal criteria of visual analysis, we established regional differences in abnormal MIBG defect scores. An abnormal region of the bull's-eye was defined as an area > 2 SD below normal. An abnormal regional washout rate was defined as < 0%. Using these criteria, we prospectively evaluated 104 patients with suspected vasospastic angina. Visual, bull's-eye and regional washout rate analyses were compared for overall detection of the disease and for individual vessel involvement. Overall sensitivity by these methods was 30%, 42% and 76%, respectively. Washout rate analysis showed a significantly higher sensit...Continue Reading

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Citations

Feb 17, 2000·Clinical Cardiology·A KumarP Denes
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Jan 20, 2009·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Arnold F JacobsonPaolo G Camici
Feb 6, 2007·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Taishiro ChikamoriTsunehiko Nishimura
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Mar 20, 2001·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·N YoshidaH Inoue
Jan 27, 2005·Circulation Journal : Official Journal of the Japanese Circulation Society·Kazuyuki SakataOsamu Doi
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Feb 15, 2019·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Lida FeyzJoost Daemen
Feb 15, 2019·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Mark I Travin
Jun 3, 2015·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Kenichi Nakajima, Tomoaki Nakata

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