Iodine-125-brachytherapy of malignant choroid melanoma. II: Long-term functional outcome

Klinische Monatsblätter für Augenheilkunde
I KreissigE Simader

Abstract

Following I-125 brachytherapy of choroidal melanoma, a good primary postoperative visual acuity results. The aim of this study is to evaluate postoperative, longterm visual acuity answering the following questions: 1) When do radiogenic complications begin to develop; 2) How long does the postoperative visual acuity remain stable; 3) Is there a difference if the treated tumor is < or = or > 3 mm off the disc and foveola respectively. Between 12/1984-12/1989, 19 patients were treated with I-125 brachytherapy for choroidal melanoma. Height of tumor was x 5.8 mm, maximum base diameter x 11.6 mm. In 10 eyes (group A), the posterior tumor border was < or = 3 mm off the disc and foveola respectively, in 9 (group B) > 3 mm. The plaque was in situ x 7.5 days, apical radiation dose x 70 Gy, and scleral contact dose x 355 Gy. Follow-up ranged at x 6.3 years. Between preoperative visual acuity in group A and group B there was a statistically significant difference (p < 0.05), which remained stable 1 1/2 years postoperatively. Subsequent deterioration of visual acuity occurred later in group B than in group A, but was present after 4 1/2 years in all patients and ranged at < or = 20/400. This decrease was due to subsequent radiogenic oculo...Continue Reading

Citations

Oct 4, 2011·Clinical Ophthalmology·B Fiebai, Ea Awoyesuku
Dec 21, 2005·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·S RihawiN F Schrage
Oct 31, 2009·Expert Opinion on Pharmacotherapy·Ciro CostagliolaFrancesco Parmeggiani
Mar 22, 2014·Anesthesia and Analgesia·André LaferrièreTerence J Coderre

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