Iodine-131 MIBG imaging in multiple endocrine neoplasia type 2B

Clinical Nuclear Medicine
Y YamamotoM Tanabe

Abstract

A 16-year-old boy had a swollen neck that was a result of multiple endocrine neoplasia Type 2B (MEN 2B). CT revealed bilateral thyroid tumors, swelling of right cervical lymph nodes, and slight enlargement of the right adrenal gland. I-131 metaiodobenzylguanidine (MIBG) scintigraphy demonstrated increased uptake in the right adrenal gland and the left thyroid tumor, but no abnormal uptake in the right thyroid tumor and the right cervical lymph nodes. Postoperative pathologic findings were consistent with the diagnosis of right adrenal medullary hyperplasia, which is a precursor of pheochromocytoma. In patients with MEN 2B, I-131 MIBG scintigraphy in conjunction with CT of the adrenal glands should be performed to determine the disease stage of the adrenal medullae. In the cervical region, the diagnosis was medullary thyroid carcinoma (MTC) in both thyroid tumors and metastases in the right cervical lymph nodes. The right MTC was more aggressive than the left MTC. It is interesting that not all sites of known MTC take up I-131 MIBG to the same degree.

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Citations

Sep 28, 2002·European Journal of Radiology·Yoshinobu YanagiKanji Kishi
Sep 21, 2001·Clinical Nuclear Medicine·C J Frater, S Angelides
Apr 14, 2006·Journal of Endocrinological Investigation·G ParentiA Peri
Sep 24, 2014·International Journal of Endocrinology·Lu YangTianyong Fan
Aug 15, 2003·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Géza MózesHossein Gharib

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