Iodine Distribution Map in Dual-Energy Computed Tomography Pulmonary Artery Imaging with Rapid kVp Switching for the Diagnostic Analysis and Quantitative Evaluation of Acute Pulmonary Embolism

Academic Radiology
Xiang-Ran CaiXiao-Bai Wang

Abstract

To assess the diagnostic value of dual-energy (DE) computed tomography pulmonary angiography (CTPA) for acute pulmonary embolism (PE) using a helical DE scan mode with rapid kVp switching. Seventy-six patients with suspected acute PE underwent DE CTPA. Two readers independently assessed and measured the iodine maps. CTPA images were assessed for the presence, location, and degree of PE as the standard of reference. Iodine maps were used to identify the perfusion defect (PD), and the diagnostic accuracy of iodine maps was calculated. The iodine concentrations of PDs and normal lung parenchyma were also measured and compared. A per-patient analysis showed the 84.6% sensitivity and 96.0% specificity of iodine map for PE, and on per-segment analysis, the sensitivity and specificity for PE were 82.9% and 99.6%, respectively. Intraobserver and interobserver variability correlations were excellent, with k values from 0.806 to 1.000. Quantitative analysis showed there was a significant difference for iodine concentration between circumscribed/patchy PDs or wedge-shaped PDs consistent with PE and normal lung parenchyma (P < .05). The intraobserver reliability of reader 1 was from 0.928 to 0.997, and reader 2 was from 0.912 to 0.995. And...Continue Reading

References

Sep 9, 2008·European Journal of Radiology·Sven F ThiemeThorsten R C Johnson
Jun 23, 2009·AJR. American Journal of Roentgenology·Sven F ThiemeKonstantin Nikolaou
Sep 1, 2009·European Journal of Radiology·Jiří FerdaBoris Kreuzberg
Aug 10, 2010·Seminars in Ultrasound, CT, and MR·Sven F ThiemeKonstantin Nikolaou
Oct 26, 2010·European Journal of Radiology·J Matthias KerlThomas J Vogl
Dec 28, 2010·European Journal of Radiology·S F ThiemeT R C Johnson
Mar 23, 2011·European Journal of Radiology·Lucas L GeyerUlrich Linsenmaier
Mar 14, 2012·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Ravi K KazaAshish Wasnik
Jun 14, 2013·European Radiology·Long Jiang ZhangGuang Ming Lu
Jun 28, 2013·World Journal of Radiology·Jan HansmannUlrike I Attenberger
Nov 13, 2013·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Vladimir KinclRadka Stepanova

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Citations

Oct 30, 2018·Journal of Computer Assisted Tomography·Jonathan AlisAnna Shmukler
May 3, 2019·The International Journal of Cardiovascular Imaging·Prabhakar RajiahAlastair Moore
Mar 23, 2017·World Journal of Gastroenterology : WJG·Xiao-Hua ChenJian-Bo Gao
Jul 12, 2018·Radiologia brasileira·Julia NoschangEdson Marchiori
Apr 25, 2019·The International Journal of Cardiovascular Imaging·Evan J ZuckerFrandics P Chan
Feb 9, 2021·European Radiology·Caterina B MontiFrancesco Sardanelli
Feb 16, 2021·TH Open : Companion Journal to Thrombosis and Haemostasis·Lisette F van DamFrederikus A Klok

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