PMID: 8938107Dec 1, 1996Paper

Iodine-induced autoimmune thyroiditis in NOD-H-2h4 mice

Clinical Immunology and Immunopathology
L RasoolyN R Rose

Abstract

Excess iodine ingestion has been implicated in induction and exacerbation of autoimmune thyroiditis in human populations and animal models. We studied the time course and sex-related differences in iodine-induced autoimmune thyroiditis in NOD-H-2h4 mice. This strain, derived from a cross of NOD with B10.A(4R), spontaneously develops autoimmune thyroiditis but not diabetes. NOD-H-2h4 mice were given either plain water or water with 0.05% iodine for 8 weeks. Approximately 54% of female and 70% of male iodine-treated mice developed thyroid lesions, whereas only 1 of 20 control animals had thyroiditis at this time. Levels of serum thyroxin (T4) were similar in the treatment and control groups. Thyroglobulin-specific antibodies were present in the iodine-treated group after 8 weeks of treatment but antibodies to thyroid peroxidase were not apparent in the serum of any of the animals. Levels of thyroglobulin antibodies increased throughout the 8-week iodine ingestion period; however, no correlation was seen between the levels of total thyroglobulin antibodies and the degree of thyroid infiltration at the time of autopsy. The thyroglobulin antibodies consisted primarily of IgG2a, IgG2b, and IgM antibodies with no detectable IgA, IgG1,...Continue Reading

Citations

Jun 21, 2011·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Samuel W Hall, Anne Cooke
Jan 21, 2010·Immunologic Research·C Lynne Burek
Sep 23, 2003·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Yongzhong WeiHelen Braley-Mullen
Jul 10, 2003·Autoimmunity Reviews·Noel R RoseC Lynne Burek
Jan 19, 2010·Chemical Research in Toxicology·K Michael PollardDwight H Kono
Dec 18, 2009·Nature Immunology·Diane Mathis, Christophe Benoist
Sep 2, 2004·Nature Medicine·Sandra M McLachlan, Basil Rapoport
Mar 27, 2002·Nature Reviews. Immunology·Giorgio Stassi, Ruggero De Maria
Jun 30, 2006·The New England Journal of Medicine·Weiping TengChenyang Li
Nov 6, 2002·The Journal of Experimental Medicine·Sylvie LesageChristopher C Goodnow
Jun 9, 2001·Thyroid : Official Journal of the American Thyroid Association·C Ruwhof, H A Drexhage
Dec 17, 2002·Thyroid : Official Journal of the American Thyroid Association·Pavel PichurinSandra M McLachlan
Jul 12, 2003·Thyroid : Official Journal of the American Thyroid Association·Patrizio CaturegliShey-Cherng Tzou
Aug 17, 2004·Thyroid : Official Journal of the American Thyroid Association·Sandra M McLachlan, Basil Rapoport
Jun 3, 2005·Thyroid : Official Journal of the American Thyroid Association·P P A SmythJ H Lazarus
Aug 30, 2007·Thyroid : Official Journal of the American Thyroid Association·Labrini PapanastasiouGeorge Mastorakos
Sep 29, 2007·Thyroid : Official Journal of the American Thyroid Association·Yi-Chi M KongChella S David
Sep 29, 2007·Thyroid : Official Journal of the American Thyroid Association·George Carayanniotis
Oct 4, 2007·Thyroid : Official Journal of the American Thyroid Association·Yujiang FangHelen Braley-Mullen
Dec 5, 2006·Current Opinion in Rheumatology·Patrizio CaturegliNoel R Rose
Mar 15, 2005·Journal of Autoimmune Diseases·Dimitry A Chistiakov
Sep 2, 2000·Environmental Health Perspectives·J J PowellM E Gershwin
Sep 30, 1999·Environmental Health Perspectives·N R RoseC L Burek
Jan 20, 2006·Journal of Endocrinological Investigation·H GuanW Teng
Feb 28, 2009·Journal of Endocrinological Investigation·U FilippiM Bagnasco
Oct 23, 2003·Proceedings of the National Academy of Sciences of the United States of America·John F ElliottKatherine M Kavanagh
Apr 18, 2014·Biological Trace Element Research·Xiao YangWeiping Teng
Jan 28, 2014·Thyroid : Official Journal of the American Thyroid Association·Margret EhlersMatthias Schott
May 24, 2011·Journal of Thyroid Research·Rajni B SharmaC Lynne Burek
Mar 26, 2014·Thyroid : Official Journal of the American Thyroid Association·Panayota Kolypetri, George Carayanniotis
Feb 5, 2015·Mitochondrial DNA. Part A. DNA Mapping, Sequencing, and Analysis·Na XuCong Qiao
Mar 7, 2013·Immunological Investigations·Saeko HoshikawaKouki Mori
May 11, 2006·Immunopharmacology and Immunotoxicology·Bong-Seok KangCheorl-Ho Kim

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Thyroiditis

Autoimmune thyroiditis is an inflammatory disease of thyroid gland due to autoimmune responses leading to lymphocytic infiltration of the gland. It is characterized by the presence of circulating thyroid antigen-specific T-cells and thyroid autoantibodies. Discover the latest research on autoimmune thyroiditis here.