Abstract
To investigate the value of third-generation dual-source dual-energy computed tomography (DECT) iodine quantification to distinguish hepatic neuroendocrine tumor (NET) metastasis from hepatocellular carcinoma (HCC) in non-cirrhotic liver parenchyma. Forty-six patients (mean age, 64.9 ± 10.1 years; 28 male and 18 female) with either hepatic NET metastasis or HCC, who had undergone liver DECT, were included in this retrospective study. For each lesion, arterial-phase attenuation values and DECT quantitative parameters, including iodine uptake, fat fraction, normalized iodine uptake (NIU), and lesion-to-liver-parenchyma ratio (LPR) were evaluated. Available cumulative data from histopathology, MRI, PET/CT, or interval imaging follow-up served as the reference standard for all liver lesions. In addition, the diagnostic accuracy of contrast-enhanced and material decomposition analysis for the differentiation of hepatic NET metastasis and HCC was assessed using receiver operating characteristics (ROC) curve analysis. Hepatic NET metastasis and HCC showed significant differences in arterial attenuation (P = 0.003), iodine uptake (P < 0.001), NIU (P < 0.001), and LPR (P = 0.003). No significant differences were found for unenhanced att...Continue Reading
Citations
Jun 10, 2020·Canadian Association of Radiologists Journal = Journal L'Association Canadienne Des Radiologistes·Jeffery R BirdIain D C Kirkpatrick
May 15, 2020·AJR. American Journal of Roentgenology·Fatemeh HomayouniehMannudeep K Kalra
Oct 1, 2020·European Radiology·David ZopfsNils Große Hokamp
Jul 20, 2019·Acta Radiologica·Georg BöningFlorian Streitparth
Dec 7, 2019·Oncology Letters·Chunling ZhangAimei Ouyang
Feb 26, 2020·BMC Medical Imaging·O BarachiniS Zandieh
Oct 3, 2018·European Radiology·André EulerRendon C Nelson
Apr 17, 2020·Current Oncology Reports·Arya Haj-MirzaianAtif Zaheer
Oct 24, 2020·Abdominal Radiology·Mohammed SalehAjaykumar C Morani
Jan 9, 2021·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Xiaoxia WangJiuquan Zhang
Feb 22, 2021·Clinical Radiology·G BöningF Streitparth
Apr 10, 2021·European Journal of Radiology·Hyo-Jin KangJoon Koo Han
Apr 14, 2021·European Journal of Nuclear Medicine and Molecular Imaging·Lorenz BirnbacherJulia Herzen
May 25, 2020·Academic Radiology·Lukas LengaSimon S Martin
May 29, 2021·European Radiology Experimental·Shalini Thapar LaroiaShiv Kumar Sarin
Jul 1, 2021·Abdominal Radiology·Markus M ObmannBenjamin M Yeh
Jul 17, 2021·European Journal of Radiology·Sebastian GassenmaierMalte N Bongers
Jul 17, 2021·Academic Radiology·Vitali KochChristian Booz
Sep 3, 2021·Journal of Applied Clinical Medical Physics·Crystal A GreenEhsan Samei
Nov 2, 2021·Acta Radiologica·Benjamin A VossJoel G Fletcher
Jan 20, 2022·AJR. American Journal of Roentgenology·Yangdi WangYanji Luo