Iodine quantification to distinguish hepatic neuroendocrine tumor metastasis from hepatocellular carcinoma at dual-source dual-energy liver CT

European Journal of Radiology
Benjamin KaltenbachSimon S Martin

Abstract

To investigate the value of third-generation dual-source dual-energy computed tomography (DECT) iodine quantification to distinguish hepatic neuroendocrine tumor (NET) metastasis from hepatocellular carcinoma (HCC) in non-cirrhotic liver parenchyma. Forty-six patients (mean age, 64.9 ± 10.1 years; 28 male and 18 female) with either hepatic NET metastasis or HCC, who had undergone liver DECT, were included in this retrospective study. For each lesion, arterial-phase attenuation values and DECT quantitative parameters, including iodine uptake, fat fraction, normalized iodine uptake (NIU), and lesion-to-liver-parenchyma ratio (LPR) were evaluated. Available cumulative data from histopathology, MRI, PET/CT, or interval imaging follow-up served as the reference standard for all liver lesions. In addition, the diagnostic accuracy of contrast-enhanced and material decomposition analysis for the differentiation of hepatic NET metastasis and HCC was assessed using receiver operating characteristics (ROC) curve analysis. Hepatic NET metastasis and HCC showed significant differences in arterial attenuation (P = 0.003), iodine uptake (P < 0.001), NIU (P < 0.001), and LPR (P = 0.003). No significant differences were found for unenhanced att...Continue Reading

Citations

May 15, 2020·AJR. American Journal of Roentgenology·Fatemeh HomayouniehMannudeep K Kalra
Dec 7, 2019·Oncology Letters·Chunling ZhangAimei Ouyang
Apr 17, 2020·Current Oncology Reports·Arya Haj-MirzaianAtif Zaheer
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Jan 9, 2021·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Xiaoxia WangJiuquan Zhang
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Jul 1, 2021·Abdominal Radiology·Markus M ObmannBenjamin M Yeh
Sep 3, 2021·Journal of Applied Clinical Medical Physics·Crystal A GreenEhsan Samei

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