PMID: 16519101Mar 8, 2006Paper

Iodine status and its influence on thyroid structure and function in children and teenagers after the introduction of an iodine prophylaxis programme in the city of Szczecin

Annales Academiae Medicae Stetinensis
Jacek Brodowski

Abstract

Studies conducted in the early 1990s revealed the spread of iodine deficiency and endemic goitre throughout Poland and contributed to the adoption of statutory table salt iodization in 1997. The present work was undertaken to assess the efficacy of the current model of iodine prophylaxis on the basis of goitre incidence, ioduria, thyreoglobulin serum concentration, and thyroid gland function in a randomly selected group of children residing in the city of Szczecin between 2002 and 2003. Subjects taking vitamin or mineral preparations enriched with iodine were excluded from the study. The study group included 273 children aged 9 to 16 years (140 boys (52%) and 133 girls (48%). Iodine excretion in urine was determined with the catalytic Sandell-Kolthoff reaction. Radioimmunometric and radioimmunological methods were used for the determination of thyreoglobulin (Tg), thyrotropin (TSH), and free thyroxine (FT4) concentrations. Goitre was confirmed in 12 children (4.3%). In this subgroup, iodine excretion in urine was significantly lower (75.4 +/-35.66 microg/L vs. 86.1 +/- 44.2 microg/L in children without goitre) and thyreoglobulin serum concentration was higher (14.36 +/- 8.9 microg/L and 11.92 +/- 7.49 microg/L, respectively). T...Continue Reading

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