Iodine status assessment in children: spot urine iodine concentration reasonably reflects true twenty-four-hour iodine excretion only when scaled to creatinine

Thyroid : Official Journal of the American Thyroid Association
Gabriela Montenegro-BethancourtThomas Remer

Abstract

Currently, the measurement of urinary iodine concentration (UIC, μg/L) is the recommended parameter to assess iodine status, however, the dependency of UIC on urine volume may limit its use as an accurate parameter for monitoring iodine status in populations. Therefore, our objective was to compare two approaches for the assessment of urinary iodine excretion in spot urine samples: UIC (μg/L) and a creatinine-scaled estimate of 24-hour iodine excretion (est24h-UIEcrea [μg/d]) against actually measured 24-hour urinary iodine excretion rates (24h-UIE, μg/d). Urinary iodine and creatinine were measured both in 24-hour urine samples and parallel collected spot urine samples from 180 healthy participants of the DONALD Study, aged 6-18 years. 24h-UIE was used as quasi-reference for actual iodine status. Published 24-hour creatinine reference values served to calculate est24h-UIEcrea. Correlation analysis, cross-classifications, and Bland-Altman plots were used to evaluate agreement between the different assessment approaches. Correlation coefficients of 24h-UIE with UIC (r=0.12, r=0.22; p=n.s.) were substantially weaker than with est24h-UIEcrea (r=0.41, r=0.47; p<0.001) in the 6-12 year old and 13-18 year old groups, respectively. Cr...Continue Reading

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Citations

Jul 17, 2016·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Roland Gärtner
Sep 28, 2016·Environment International·Ioanna KatsikantamiApostolos K Rizos
May 18, 2018·The Korean Journal of Internal Medicine·Jonghwa AhnWon Gu Kim
Feb 23, 2019·Health Promotion Perspectives·Zahra HeidariMehranghiz Ebrahimi-Mameghani
Nov 21, 2019·European Journal of Nutrition·Magali Rios-LeyvrazArnaud Chiolero
Dec 1, 2019·European Journal of Nutrition·Jonas EscheThomas Remer
Apr 4, 2021·Nutrients·Maurizio DelvecchioRuggiero Francavilla
Apr 10, 2021·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Ye BuYing Liu
Jul 28, 2021·The Journal of Nutrition·Jesse BertinatoMary R L'Abbé

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Methods Mentioned

BETA
urine collection
urine
urine bank
urine collections

Software Mentioned

SAS®

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