Iodine supplementation and drinking-water perchlorate mitigation

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Thomas A LewandowskiGail Charnley

Abstract

Ensuring adequate iodine intake is important, particularly among women of reproductive age, because iodine is necessary for early life development. Biologically based dose-response modeling of the relationships among iodide status, perchlorate dose, and thyroid hormone production in pregnant women has indicated that iodide intake has a profound effect on the likelihood that exposure to goitrogens will produce hypothyroxinemia. We evaluated the possibility of increasing iodine intake to offset potential risks from perchlorate exposure. We also explored the effect of dietary exposures to nitrate and thiocyanate on iodine uptake and thyroid hormone production. Our modeling indicates that the level of thyroid hormone perturbation associated with perchlorate exposures in the range of current regulatory limits is extremely small and would be overwhelmed by other goitrogen exposures. Our analysis also shows that microgram levels of iodine supplementation would be sufficient to prevent the goitrogenic effects of perchlorate exposure at current regulatory limits among at risk individuals. The human health risks from supplementing drinking water with iodine are negligible; therefore, this approach is worthy of regulatory consideration.

References

Aug 1, 1986·The Journal of Clinical Endocrinology and Metabolism·S SquatritoS H Ingbar
May 1, 1995·American Journal of Public Health·D YazipoP Bourdoux
Mar 15, 1993·Annals of the New York Academy of Sciences·J T Dunn
Oct 27, 1997·The Journal of Biological Chemistry·S EskandariN Carrasco
Feb 26, 1999·Thyroid : Official Journal of the American Thyroid Association·F VermiglioF Trimarchi
May 4, 1999·Journal of Occupational and Environmental Medicine·S H LammG Howearth
May 15, 2001·Thyroid : Official Journal of the American Thyroid Association·J T Dunn
Apr 18, 2003·Toxicological Sciences : an Official Journal of the Society of Toxicology·Rebecca A ClewellJeffery M Gearhart
Jun 14, 2003·Toxicological Sciences : an Official Journal of the Society of Toxicology·Rebecca A ClewellJeffery M Gearhart
Nov 24, 1961·Science·R A BLOOMFIELDM E MUHRER
Aug 17, 2004·Thyroid : Official Journal of the American Thyroid Association·UNKNOWN American Thyroid AssociationUNKNOWN American Association of Clinical Endocrinologists
Oct 29, 2004·Toxicological Sciences : an Official Journal of the Society of Toxicology·Elaine A MerrillJeffrey W Fisher
Dec 2, 2004·The Journal of Clinical Endocrinology and Metabolism·Lewis E BravermanJohn P Gibbs
Aug 2, 2005·Thyroid : Official Journal of the American Thyroid Association·Kathleen L CaldwellJoseph G Hollowell
Sep 29, 2005·Thyroid : Official Journal of the American Thyroid Association·Rafael Téllez TéllezJohn P Gibbs
Apr 26, 2006·The Journal of Clinical Endocrinology and Metabolism·Lewis E BravermanAnthony Firek
Dec 23, 2006·Environmental Health Perspectives·Benjamin C BlountKathleen L Caldwell
Sep 28, 2007·Therapeutic Drug Monitoring·Offie P SoldinMarisol Sastoque
Oct 27, 2007·Bulletin of Environmental Contamination and Toxicology·C A SanchezR I Krieger
Jan 3, 2008·Journal of Exposure Science & Environmental Epidemiology·Clarence William MurrayPhilip Michael Bolger
Mar 21, 2008·Environmental Science & Technology·Purnendu K DasguptaJason V Dyke
Dec 18, 2008·The American Journal of Clinical Nutrition·Michael B Zimmermann
Aug 12, 2009·Journal of Pain & Palliative Care Pharmacotherapy·UNKNOWN U.S. Food and Drug Administration
Oct 24, 2009·Journal of Environmental Management·Katarzyna H KucharzykThomas F Hess
Feb 23, 2010·Environmental Health : a Global Access Science Source·John S GriesenbeckUNKNOWN National Birth Defects Prevention Study
Jul 9, 2010·The Journal of Clinical Endocrinology and Metabolism·Gregory A Brent
Jul 16, 2010·Thyroid : Official Journal of the American Thyroid Association·Maria José CosteiraJoana Almeida Palha
Nov 26, 2010·Environmental Science & Technology·Benjamin C BlountW Andrew Jackson
Dec 8, 2010·Journal of Pain & Palliative Care Pharmacotherapy·UNKNOWN Centers for Disease Control and Prevention Public Health Service U. S. Department of Health and Human Services
Jan 21, 2011·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Roberto NegroAlex Stagnaro-Green
Feb 22, 2011·Breastfeeding Medicine : the Official Journal of the Academy of Breastfeeding Medicine·UNKNOWN U.S. Department of Health and Human Services
May 7, 2011·Analytical Biochemistry·Julie Di BernardoKerry J Rhoden
Jan 25, 2012·Bulletin of the World Health Organization·Norm CampbellMichael B Zimmermann
Jul 7, 2012·Journal of Pain & Palliative Care Pharmacotherapy·UNKNOWN Food And Drug Administration, Public Health Service, U.S. Department Of Health And Human Services
Jan 10, 2013·Revista Panamericana De Salud Pública = Pan American Journal of Public Health·Norm R C CampbellMichael B Zimmermann
Mar 16, 2013·Thyroid : Official Journal of the American Thyroid Association·Kathleen L CaldwellJohn Moye
Mar 29, 2013·Toxicological Sciences : an Official Journal of the Society of Toxicology·Annie LumenJeffrey W Fisher
Apr 8, 2014·The Journal of Clinical Endocrinology and Metabolism·Natthinee CharatcharoenwitthayaLewis E Braverman

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Citations

Nov 21, 2015·La Presse médicale·Rachel Desailloud, Jean-Louis Wemeau
Nov 7, 2016·General and Comparative Endocrinology·Alison M GardellC Loren Buck
Nov 11, 2016·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Mongkol KonkayanSaksit Chanthai
May 27, 2020·Journal of Thyroid Research·Sunny P OrathelPonnu Jose

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