Iodine Supplementation of Mildly Iodine-Deficient Adults Lowers Thyroglobulin: A Randomized Controlled Trial

The Journal of Clinical Endocrinology and Metabolism
Zheng Feei MaSheila Skeaff

Abstract

An inverse relationship between thyroglobulin (Tg) and urinary iodine concentration (UIC) has been found in children, potentially making Tg a viable blood marker of iodine status. The application of Tg in adults is unknown. The objective of the study was to determine the efficacy of Tg to assess iodine status in adults. This was a randomized, double-blind, placebo-controlled, clinical trial. The study was conducted in Dunedin, New Zealand. Mildly iodine deficient adults (n = 112) aged 18–40 years participated in the study. Participants were supplemented with 150 μg of iodine as potassium iodate or placebo daily for 24 weeks. At baseline and 24 weeks, participants provided five casual urine samples for UIC determination; serum TSH and free T4 (FT4) was also measured. Tg was determined at baseline and 8, 16, and 24 weeks. A change in Tg concentration between the iodine-supplemented and placebo groups at 24 weeks. At baseline, the overall median UIC was 65 μg/L, confirming that participants were mildly iodine deficient (ie, median UIC between 50 and 99 μg/L). The overall median Tg was 16.6 μg/L; TSH and FT4 were within normal reference ranges. At 24 weeks, the median UIC of the placebo and supplemented groups was significantly dif...Continue Reading

Citations

May 24, 2016·Clinical Endocrinology·M L Mitchell, H W Hsu
Oct 21, 2016·Thyroid : Official Journal of the American Thyroid Association·Sarah C BathMargaret P Rayman
Apr 18, 2019·Biological Trace Element Research·Zheng Feei Ma
Aug 16, 2018·Biological Trace Element Research·Zheng Feei Ma
Aug 6, 2021·Maternal & Child Nutrition·Alexandra C Purdue-SmitheJames L Mills

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