Iodized Salt Intake and Its Association with Urinary Iodine, Thyroid Peroxidase Antibodies, and Thyroglobulin Antibodies Among Urban Chinese

Thyroid : Official Journal of the American Thyroid Association
Chi ChenYingli Lu

Abstract

Whether iodized salt increases the risk of thyroid disease has been strongly debated in China, especially in the urban areas of coastal regions, in recent years. This study aimed to investigate the status of iodized salt in terms of urinary and serum iodine concentration in urban coastal areas, and to explore further whether consumption of iodized salt or non-iodized salt is associated with autoimmune thyroid disease (AITD). The data source was SPECT-China, a cross-sectional study in East China. A total of 1678 subjects were enrolled from 12 communities in downtown Shanghai. The type of salt consumed, the urinary iodine concentration (UIC), serum iodine, thyroid peroxidase antibodies (TPOAb), and thyroglobulin antibodies (TgAb) levels were obtained. AITD was defined as serum TPOAb and/or TgAb >60 kIU/L (TPO/TgAb [+]). The prevalence of AITD was 10.5% in men and 21.4% in women. The median UIC and serum iodine concentration were 106.4 μg/L and 60.9 μg/L, respectively. Among all the subjects, 46.4% consumed non-iodized salt; the prevalence of iodine deficiency among those subjects was significantly higher than that of the subjects who consumed iodized salt (54.2% vs. 40.1%; p < 0.001). Consumption of non-iodized salt was positivel...Continue Reading

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Citations

Dec 6, 2019·Thyroid : Official Journal of the American Thyroid Association·Caroline Serrano-NascimentoPilar Santisteban
Dec 9, 2020·American Journal of Human Biology : the Official Journal of the Human Biology Council·Tara J Cepon-Robins
Aug 5, 2020·Thyroid : Official Journal of the American Thyroid Association·Lu LiHuai-Dong Song
Mar 9, 2021·Journal of Endocrinological Investigation·R M Ruggeri, F Trimarchi
Jun 15, 2021·International Journal of Endocrinology·Yingchao ChenYingli Lu
Oct 5, 2021·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·Lei ShiJue Zhang

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