Iodopropynylbutyl carbamate 0.2% is suggested for patch testing of patients with eczema possibly related to preservatives

The British Journal of Dermatology
J BraschInformation Network of Departments of Dermatology

Abstract

Iodopropynyl butylcarbamate (IPBC) is a new preservative in medical and cosmetic leave-on products. Although cases of allergic contact dermatitis to IPBC have been reported, it is not known whether the usual test concentration of 0.1% is appropriate for screening tests with IPBC. To determine the concentration of IPBC that should be used in screening patch tests. An analysis was made of data filed by 26 centres of dermatology on patch tests performed with one or two concentrations of IPBC (0.1%, 0.2%, 0.3% or 0.5%) in 8106 unselected patients. Criteria used to determine the best test concentration of IPBC were the reaction index, the positivity ratio, the rate of crescendo reactions, and the relations between IPBC reactions and the MOAHLFA index irritant reactions to sodium lauryl sulphate (SLS), and allergic reactions to other contact allergens including preservatives. IPBC 0.1%, 0.2%, 0.3% and 0.5% yielded 0.5%, 0.8%, 1.3% and 1.7% positive reactions, but this increase was accompanied by an even greater increase in doubtful and irritant reactions. These figures and the other criteria examined suggested the range of suitable test concentrations of IPBC to lie between 0.2% and 0.3%. A detailed analysis of MOAHLFA indices and of...Continue Reading

References

Nov 1, 1990·The British Journal of Dermatology·A B CuaH I Maibach
Jan 1, 1980·Contact Dermatitis·J E Wahlberg, H I Maibach
May 1, 1994·Contact Dermatitis·S Patil, H I Maibach
Oct 1, 1995·Contact Dermatitis·I Effendy, H I Maibach
Mar 1, 1997·Contact Dermatitis·L E BryldT Menné
Apr 20, 1999·Contact Dermatitis·H R SmithI R White
May 22, 2002·American Journal of Contact Dermatitis : Official Journal of the American Contact Dermatitis Society·Sonia Badreshia, James G Marks
May 21, 2003·Contact Dermatitis·Charlotte Devantier JensenKlaus Ejner Andersen
Sep 27, 2003·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·R SchöllnastW Aberer
Mar 5, 2004·Contact Dermatitis·Jochen BraschWolfgang Uter
Aug 11, 2007·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·A SchnuchUNKNOWN Deutschen Dermatologischen Gesellschaft (DDG) zur Durchführung des Epikutantests mit Kontaktallergenen

❮ Previous
Next ❯

Citations

Jul 22, 2009·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·J GeierH Lessmann
Jul 22, 2005·Contact Dermatitis·J GeierA Schnuch
Apr 19, 2011·Clinics in Dermatology·Rosie F Davies, Graham A Johnston
Jul 8, 2009·Dermatologic Clinics·Lisa E MaierSharon E Jacob
May 9, 2006·Dermatologic Clinics·Katherine A Biebl, Erin M Warshaw
Jul 5, 2008·Contact Dermatitis·Jochen Brasch, Johannes Geier
Jul 23, 2013·Contact Dermatitis·Alejandro Martin-Gorgojo, Jeanne-Duus Johansen
Sep 11, 2014·Dermatitis : Contact, Atopic, Occupational, Drug·Elizabeth YimAntonella Tosti
May 27, 2017·Current Opinion in Allergy and Clinical Immunology·Gustavo Deza, Ana M Giménez-Arnau
Oct 14, 2017·International Journal of Toxicology·Wilbur Johnson
Sep 1, 2005·Current Opinion in Allergy and Clinical Immunology·Wolfgang UterAxel Schnuch
Dec 4, 2019·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·B Kreft, J Geier
Sep 14, 2013·Dermatitis : Contact, Atopic, Occupational, Drug·Erin M WarshawFrances J Storrs
Oct 20, 2021·Acta Dermato-venereologica·Gunnar S A NymanLina Hagvall

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.