Ion-Based Metal/Graphene Antibacterial Agents Comprising Mono-Ionic and Bi-Ionic Silver and Copper Species

Langmuir : the ACS Journal of Surfaces and Colloids
Anna PerdikakiGeorgios N Karanikolos

Abstract

Design of novel and more efficient antibacterial agents is a continuous and dynamic process due to the appearance of new pathogenic strains and inherent resistance development to existing antimicrobial treatments. Metallic nanoparticles (NPs) are highly investigated, yet the role of released ions is crucial in the antibacterial activity of the NP-based systems. We developed herein ion-based, metal/graphene hybrid structures comprising surface-bound Ag and Cu mono-ionic and Ag/Cu bi-ionic species on functionalized graphene, without involvement of NPs. The antibacterial performance of the resulting systems was evaluated against Escherichia coli cells using a series of parametrization experiments of varying metal ion types and concentrations and compared with that of the respective NP-based systems. It was found that the bi-ionic Ag/Cu-graphene materials exhibited superior performance compared to that of the mono-ionic analogues owing to the synergistic action of the combination of the two different metal ions on the surface and the enhancing role of the graphene support, whereas all ion-based systems performed superiorly compared to their NP-based counterparts of the same metal type and concentration. In addition, the materials e...Continue Reading

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Citations

Jul 17, 2020·Frontiers in Chemistry·Naman AroraGeorgios N Karanikolos
Jan 27, 2021·ACS Nano·Joshua SeabergPriyabrata Mukherjee

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