Ion Channel Function During Oocyte Maturation and Fertilization

Frontiers in Cell and Developmental Biology
Ingrid CarvachoKhaled Machaca

Abstract

The proper maturation of both male and female gametes is essential for supporting fertilization and the early embryonic divisions. In the ovary, immature fully-grown oocytes that are arrested in prophase I of meiosis I are not able to support fertilization. Acquiring fertilization competence requires resumption of meiosis which encompasses the remodeling of multiple signaling pathways and the reorganization of cellular organelles. Collectively, this differentiation endows the egg with the ability to activate at fertilization and to promote the egg-to-embryo transition. Oocyte maturation is associated with changes in the electrical properties of the plasma membrane and alterations in the function and distribution of ion channels. Therefore, variations on the pattern of expression, distribution, and function of ion channels and transporters during oocyte maturation are fundamental to reproductive success. Ion channels and transporters are important in regulating membrane potential, but also in the case of calcium (Ca2+), they play a critical role in modulating intracellular signaling pathways. In the context of fertilization, Ca2+ has been shown to be the universal activator of development at fertilization, playing a central role...Continue Reading

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Citations

Aug 21, 2019·Cold Spring Harbor Perspectives in Biology·Takuya WakaiRafael A Fissore
May 23, 2020·Annual Review of Plant Biology·Friederike HaterRita Groß-Hardt
Apr 19, 2019·International Journal of Molecular Sciences·Sudip PaudelMargaret S Saha
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Sep 18, 2021·Zygote : the Biology of Gametes and Early Embryos·Ho Chi LeungSarah E Webb

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