PMID: 9447618Feb 3, 1998Paper

Ion channels and the control of swimming in the Xenopus embryo

Progress in Neurobiology
N Dale, F M Kuenzi

Abstract

The Xenopus embryo has been well studied and the circuitry underlying motor pattern generation largely elucidated. We have extended this analysis by determining the roles of individual voltage- and ligand-gated ion channels in controlling the motor pattern for swimming and two mechanisms that control rundown of this pattern. Xenopus embryo spinal neurons possess at least six classes of ion channel: a fast Na+ channel; a mixture of kinetically similar Ca2+ channels; a fast K+ channel; a slow K+ channel; a Na(+)-dependent K+ channel; and a slowly activating Ca2(+)-dependent K+ channel. The roles of the voltage-gated currents in determining neuronal firing properties and operation of the locomotor circuitry have been examined both pharmacologically and in realistic computer simulations. Model neurons fire repetitively in response to current injection. The Ca2+ current seems essential for repetitive firing. The fast K+ current appears mainly to control spike width, whereas the slow K+ current exerts a powerful influence on repetitive firing. These predictions from the model have been confirmed by the use of specific pharmacological blockers of the fast and slow K+ currents. Both the model network and the real spinal locomotor circu...Continue Reading

References

Oct 1, 1992·Journal of Neurophysiology·D A McCormick, J R Huguenard
Jan 1, 1991·Somatosensory & Motor Research·T IwaharaR D Skinner
Sep 23, 1988·Neuroscience Letters·L Erdélyi, G Such
Jun 1, 1985·Journal of Neurophysiology·G A RobertsonP S Stein
Jun 1, 1985·The Journal of Physiology·N Dale
Jun 1, 1984·Journal of Neurophysiology·S R SoffeA Roberts
Jan 1, 1991·The European Journal of Neuroscience·Nicholas Dale
Jan 27, 1982·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·A Roberts, J D Clarke

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Citations

Nov 1, 2007·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Stefan ClemensPaul S Katz
Jun 2, 2012·Journal of Biological Physics·Wolfgang Otto FriesenJohn T Hackett
Feb 19, 2003·Brain Research. Brain Research Reviews·Abdeljabbar El ManiraPatrik Krieger
Feb 18, 1998·Current Opinion in Neurobiology·N Dale, F Kuenzi
Dec 23, 1999·Current Opinion in Neurobiology·H J Pflüger
Jun 23, 2009·Nature Reviews. Neuroscience·Martyn Goulding
Feb 3, 1999·Annals of the New York Academy of Sciences·A RobertsF Y Zhao
Jul 31, 2003·The European Journal of Neuroscience·Simon P AikenNicholas Dale
Apr 7, 2004·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Simon AlfordGonzalo Viana di Prisco
Aug 11, 2010·Neuroreport·R Meldrum RobertsonKeith T Sillar
Jul 3, 2003·Nature Reviews. Neuroscience·Sten Grillner
Feb 9, 2007·Journal of Neurophysiology·Mikael HussJeanette H Kotaleski
Jun 15, 2007·Journal of Neurophysiology·Sabrina TazerartFrédéric Brocard
Nov 6, 2007·Journal of Neurophysiology·Jens Peter GabrielAbdeljabbar El Manira
Jun 30, 2001·Journal of Neurophysiology·R R Buss, P Drapeau
Mar 11, 2000·Journal of Neurophysiology·B Saint Mleux, L E Moore
Jun 8, 2001·News in Physiological Sciences : an International Journal of Physiology Produced Jointly by the International Union of Physiological Sciences and the American Physiological Society·Abdeljabbar El Manira, Peter Wallén

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