Ion channels involved in cold detection in mammals: TRP and non-TRP mechanisms

Biophysics Reviews
Alexandru Babes

Abstract

Substantial progress in understanding thermal transduction in peripheral sensory nerve endings was achieved with the recent cloning of six thermally gated ion channels from the TRP (transient receptor potential) super-family. Two of these channels, TRP melastatin 8 (TRPM8) and TRP ankyrin 1 (TRPA1), are expressed in dorsal root ganglion (DRG) and trigeminal ganglion (TG) neurons, are activated by various degrees of cooling, and are candidates for mediating gentle cooling and noxious cold, respectively. However, accumulating evidence suggests that more than just these two channels are involved in cold sensing in mammals. A recent report described a critical role of the voltage-gated tetrodotoxin-resistant sodium channel Nav1.8 in perceiving intense cold and noxious stimuli at cold temperatures. Other ion channels, such as two-pore domain background potassium channels (K2P), are known to be expressed in peripheral nerves, have pronounced temperature dependence, and may contribute to cold sensing and/or cold hypersensitivity in pain states. This article reviews the evidence supporting a role for each of these channels in cold transduction, focusing on their biophysical properties, expression pattern, and modulation by pro-inflamma...Continue Reading

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Citations

Nov 3, 2010·The Journal of Clinical Investigation·Adrienne E Dubin, Ardem Patapoutian
Mar 23, 2019·Chemical Biology & Drug Design·Kinga SałatNatalia Malikowska-Racia
Aug 16, 2014·The Journal of Pharmacology and Experimental Therapeutics·Wendy J WinchesterDavid S Reynolds
Nov 6, 2010·The European Journal of Neuroscience·Alina TelibanWilfrid Jänig
Feb 28, 2014·Journal of Neurophysiology·Alina TelibanWilfrid Jänig
Mar 16, 2021·Frontiers in Neurology·Carla Mucignat-CarettaAngelo Antonini

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