Ion concentration polarization on paper-based microfluidic devices and its application to preconcentrate dilute sample solutions

Biomicrofluidics
Ruey-Jen YangHsiang-Li Wang

Abstract

Microfluidic paper-based analytical devices (μPADs) are a promising solution for a wide range of point-of-care applications. The feasibility of inducing ion concentration polarization (ICP) on μPADs has thus far attracted little attention. Accordingly, this study commences by demonstrating the ICP phenomenon in a μPAD with a Nafion ion-selective membrane. We are the first to measure the current-voltage curve on a Nafion-coated μPAD in order to indicate that the ion depletion occurs and the ICP is triggered when the current reaches the limiting current. The ICP effect is then exploited to preconcentrate fluorescein on μPADs incorporating straight and convergent channels. By an optimal geometric design, it is shown that the convergent channel results in a greater preconcentration effect than the straight channel. Specifically, a 20-fold enhancement in the sample concentration is achieved after 130 s given an initial concentration of [Formula: see text] M and an external potential of 50 V. By contrast, the straight channel yields only a 10-fold improvement in the concentration after 180 s. Further, the practical feasibility of the proposed convergent-channel μPAD is demonstrated using fluorescein isothiocyanate labeled bovine seru...Continue Reading

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Citations

Oct 9, 2015·Journal of the American Chemical Society·Max M GongDavid Sinton
Mar 12, 2016·The Analyst·Min Li, Robbyn K Anand
May 10, 2016·Biomicrofluidics·Yu-Hung ChenChun-Ping Jen
Jul 28, 2016·Biomicrofluidics·Chen-Meng KuanChao-Min Cheng
Dec 13, 2016·Analytical Chemistry·Yuanyuan YangCharles S Henry
Mar 18, 2017·Analytical Chemistry·Xiang LiRichard M Crooks
Apr 12, 2019·Analytical and Bioanalytical Chemistry·Chen WangXing-Hua Xia
Feb 17, 2021·Scientific Reports·Sungmin ParkSung Jae Kim
Jun 15, 2021·Chemical Reviews·Eka NovianaCharles S Henry

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