PMID: 6170401Jan 1, 1981Paper

Ion displacement following the adsorption of anionic macromolecules on hydroxyapatite

Calcified Tissue International
E I Pearce

Abstract

Certain small anionic molecules displace phosphate ions from the hydroxyapatite crystal hydration layer on adsorption. This follows the interaction of negatively charged groups with calcium ions in the crystal surface. The present study examines ion-exchange processes occurring during the adsorption of anionic macromolecules and attempts to determine the role of coulombic forces in the process. Various natural and synthetic polyanionic substances were added to a buffered hydroxyapatite slurry and adsorption measured by solution depletion. Calcium and phosphate ion displacement or uptake by apatite was determined after accounting for polymer-bound ions. Carboxymethylcellulose and a polyacrylamide sample in which 54% of amide groups had been hydrolyzed to carboxyl were adsorbed in the lowest amounts, but both caused consistent rises in the bulk solution phosphate level. Crude bovine submaxillary mucin and a polyacrylamide sample in which 28% of amide groups had been hydrolyzed were adsorbed in greater amounts but caused little or no phosphate displacement. In no case was there a stoichiometric relation between carboxyl adsorbed and phosphate displaced. The polyacrylamide samples also displaced Ca ions into the bulk solution, wher...Continue Reading

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Citations

Jul 1, 1994·Annals of Biomedical Engineering·W R WalshN Guzelsu
Jul 5, 2007·European Biophysics Journal : EBJ·Alireza S SarvestaniEsmaiel Jabbari
Dec 1, 1995·Biomaterials·W R Walsh, D L Christiansen
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Oct 15, 2013·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Qing LuoQiguo Rong
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Jan 1, 1990·Journal of Biomechanics·N Guzelsu, W R Walsh
Feb 27, 2013·Computer Methods in Biomechanics and Biomedical Engineering·Abdelwahed Barkaoui, Ridha Hambli
Feb 13, 2008·Langmuir : the ACS Journal of Surfaces and Colloids·Zsombor FeldötöAndra Dedinaite
Nov 18, 2005·Journal of Colloid and Interface Science·Achilles Tsortos, George H Nancollas

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