Ion flow regulates left-right asymmetry in sea urchin development

Development Genes and Evolution
Taku HibinoAtsuo Nishino

Abstract

The degree of conservation among phyla of early mechanisms that pattern the left-right (LR) axis is poorly understood. Larvae of sea urchins exhibit consistently oriented LR asymmetry. The main part of the adult rudiment is formed from the left coelomic sac of larvae, the left hydrocoel. Although this left preference is conserved among all echinoderm larvae, its mechanism is largely not understood. Using two marker genes, HpNot and HpFoxFQ-like, which are asymmetrically expressed during larval development of the sea urchin Hemicentrotus pulcherrimus, we examined in this study the possibility that the recently discovered ion flux mechanism controls asymmetry in sea urchins as it does in several vertebrate species. Several ion-transporter inhibitors were screened for the ability to alter the expression of the asymmetric marker genes. Blockers of the H(+)/K(+)-ATPase (omeprazole, lansoprazole and SCH28080), as well as a calcium ionophore (A23187), significantly altered the normal sidedness of asymmetric gene expression. Exposure to omeprazole disrupted the consistent asymmetry of adult rudiment formation in larvae. Immuno-detection revealed that H(+)/K(+)-ATPase-like antigens in sea urchin embryos were present through blastula sta...Continue Reading

References

May 1, 1979·Experimental Cell Research·R M Showman, C A Foerder
Jun 1, 1992·Alimentary Pharmacology & Therapeutics·S W SandersJ G Page
Dec 1, 1987·The Journal of General Physiology·D W LandryQ Al-Awqati
Apr 1, 1988·The Journal of General Physiology·R D NathanW Giles
Jan 1, 1987·Differentiation; Research in Biological Diversity·K MitsunagaI Yasumasu
Jan 1, 1995·Annual Review of Pharmacology and Toxicology·G SachsS Hersey
May 6, 1996·Biochimica Et Biophysica Acta·J V MøllerM le Maire
Jun 1, 1997·Development, Growth & Differentiation·K AkasakaH Shimada
Sep 23, 1997·Biochemical and Biophysical Research Communications·R GambinoM Di Carlo
Aug 1, 1997·Development, Growth & Differentiation·R ToyoizumiS Takeuchi
Jan 9, 1998·Medical Hypotheses·M Levin, N Nascone
Aug 26, 1998·Nature·A K RyanJ C Izpisúa Belmonte
Mar 15, 2000·Developmental Biology·K J PetersonE H Davidson
Feb 12, 2002·Nature Reviews. Genetics·Hiroshi HamadaYukio Saijoh
Jul 18, 2002·Antimicrobial Agents and Chemotherapy·Suping JiangAntony J Mukkada
Oct 19, 2002·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Clive J Boorman, Sebastian M Shimeld
Jul 15, 2003·Journal of Cell Science·Mark Mercola
Sep 3, 2003·Development, Growth & Differentiation·Mayuko Hamada, Masato Kiyomoto
Sep 25, 2003·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Michael Levin
Dec 31, 2003·The Journal of Biological Chemistry·Shinji AsanoMagotoshi Morii
Mar 20, 2004·Developmental Cell·Véronique DubocThierry Lepage
Apr 2, 2004·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Jonathan Cooke
Jul 31, 2004·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·Michael Levin
Dec 8, 2004·Mechanisms of Development·Michael Levin

❮ Previous
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Citations

May 6, 2008·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Junji MorokumaMichael Levin
Jan 15, 2009·Development·Sherry Aw, Michael Levin
Aug 10, 2011·PloS One·Laura N VandenbergMichael Levin
Jun 19, 2013·Current Opinion in Genetics & Development·M Dolores MolinaThierry Lepage
Nov 13, 2012·Differentiation; Research in Biological Diversity·Nikoloz TsikoliaChristoph Viebahn
Dec 6, 2011·Differentiation; Research in Biological Diversity·Axel SchweickertMike Danilchik
May 16, 2009·Drug Discovery Today·James M MullinJames J Thornton
Mar 11, 2008·Seminars in Cell & Developmental Biology·J B CoutelisS Noselli
Jul 24, 2007·Current Opinion in Genetics & Development·Pauline SpéderStéphane Noselli
Aug 19, 2015·Developmental Biology·Daphne SchatzbergCynthia A Bradham
Feb 14, 2007·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Michael Levin, A Richard Palmer
Nov 2, 2006·Genesis : the Journal of Genetics and Development·Dany S Adams, Michael Levin
Oct 30, 2010·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Laura N Vandenberg, Michael Levin
Jun 16, 2010·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Nurdan OzkucurRichard H W Funk
Jul 31, 2013·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Michael Levin
Mar 31, 2016·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Ayumi TakemotoNaoaki Sakamoto
Jan 29, 2013·Mechanisms of Development·Laura N VandenbergMichael Levin
Dec 31, 2010·Dose-response : a Publication of International Hormesis Society·Egil Fosslien
Feb 8, 2014·Communicative & Integrative Biology·Laura N VandenbergMichael Levin
Jan 17, 2009·Seminars in Cell & Developmental Biology·Min Zhao
Apr 24, 2007·Developmental Biology·R Craig Albertson, Pamela C Yelick
Apr 28, 2009·Developmental Biology·Katherine D WaltonDavid R McClay
Nov 4, 2006·Developmental Biology·Qiang TuPaola Oliveri
Nov 9, 2016·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Gary McDowellMichael Levin
Apr 25, 2017·Ecotoxicology and Environmental Safety·Nadia RuoccoMaria Costantini
Jan 8, 2014·Genesis : the Journal of Genetics and Development·Yi-Hsien Su
Aug 23, 2008·Journal of Dental Research·A-S Tseng, M Levin
Jul 27, 2017·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Chisato KitazawaAkira Yamanaka
Mar 19, 2016·Science Advances·Taryn FosterPeta L Clode
May 29, 2018·Evolution & Development·Mami KasaharaChisato Kitazawa
Feb 8, 2020·Proceedings of the National Academy of Sciences of the United States of America·Takeshi A OnumaHiroki Nishida

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