Ion mobility separation of variant histone tails extending to the "middle-down" range.

Analytical Chemistry
Alexandre A ShvartsburgNeil L Kelleher

Abstract

Differential ion mobility spectrometry (FAIMS) can baseline-resolve multiple variants of post-translationally modified peptides extending to the 3-4 kDa range, which differ in the localization of a PTM as small as acetylation. Essentially orthogonal separations for different charge states expand the total peak capacity with the number of observed states that increases for longer polypeptides. This potentially enables resolving localization variants for yet larger peptides and even intact proteins.

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Citations

Jan 25, 2013·Journal of the American Society for Mass Spectrometry·Alexandre A ShvartsburgRichard D Smith
Jul 21, 2012·Analytical Chemistry·Alexandre A ShvartsburgNeil L Kelleher
Feb 13, 2013·Briefings in Functional Genomics·Till BartkePeter A DiMaggio
Jan 10, 2014·Journal of the American Society for Mass Spectrometry·Alexandre A ShvartsburgRichard D Smith
Feb 5, 2016·Journal of the American Society for Mass Spectrometry·Helen J Cooper
Mar 6, 2016·Journal of the American Society for Mass Spectrometry·Julia L KaszyckiAlexandre A Shvartsburg
Jul 17, 2013·Analytical Chemistry·Alexandre A Shvartsburg, Richard D Smith
Feb 2, 2019·Mass Spectrometry Reviews·Valérie GabelicaThomas Wyttenbach
Sep 13, 2019·Journal of the American Society for Mass Spectrometry·Kevin A JanssenBenjamin A Garcia
Oct 13, 2017·Journal of Separation Science·Valentina D'AtriDavy Guillarme
Nov 19, 2020·Molecular & Cellular Proteomics : MCP·Congcong LuBenjamin A Garcia
Feb 16, 2021·Analytical Chemistry·Francis BerthiasAlexandre A Shvartsburg
Jun 6, 2020·Journal of the American Society for Mass Spectrometry·Pratima PathakAlexandre A Shvartsburg
May 4, 2017·Journal of the American Society for Mass Spectrometry·Andrew P BowmanAlexandre A Shvartsburg
Jan 24, 2018·Analytical Chemistry·Alyssa GarabedianAlexandre A Shvartsburg
Feb 25, 2017·Analytical Chemistry·Alba CristobalAlbert J R Heck
Apr 14, 2017·Analytical Chemistry·Pavel V ShliahaAlexandre A Shvartsburg
Feb 2, 2019·Analytical Chemistry·Matthew A BairdAlexandre A Shvartsburg
Nov 10, 2021·Journal of the American Society for Mass Spectrometry·Francis BerthiasAlexandre A Shvartsburg

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