Ion mobility spectrometric analysis of vaporous chemical warfare agents by the instrument with corona discharge ionization ammonia dopant ambient temperature operation

Analytica Chimica Acta
Takafumi SatohYasuo Seto

Abstract

The ion mobility behavior of nineteen chemical warfare agents (7 nerve gases, 5 blister agents, 2 lachrymators, 2 blood agents, 3 choking agents) and related compounds including simulants (8 agents) and organic solvents (39) was comparably investigated by the ion mobility spectrometry instrument utilizing weak electric field linear drift tube with corona discharge ionization, ammonia doping, purified inner air drift flow circulation operated at ambient temperature and pressure. Three alkyl methylphosphonofluoridates, tabun, and four organophosphorus simulants gave the intense characteristic positive monomer-derived ion peaks and small dimer-derived ion peaks, and the later ion peaks were increased with the vapor concentrations. VX, RVX and tabun gave both characteristic positive monomer-derived ions and degradation product ions. Nitrogen mustards gave the intense characteristic positive ion peaks, and in addition distinctive negative ion peak appeared from HN3. Mustard gas, lewisite 1, o-chlorobenzylidenemalononitrile and 2-mercaptoethanol gave the characteristic negative ion peaks. Methylphosphonyl difluoride, 2-chloroacetophenone and 1,4-thioxane gave the characteristic ion peaks both in the positive and negative ion mode. 2-...Continue Reading

References

Jul 1, 1992·Annals of Emergency Medicine·F R Sidell, J Borak
Dec 1, 1990·Analytical Chemistry·H H HillD G McMinn
Aug 1, 1974·Analytical Chemistry·F W Karasek, D W Denney
Sep 7, 2001·International Journal of Mass Spectrometry and Ion Processes·R G EwingJ A Stone
Apr 2, 2002·Analytical Chemistry·Cheryl M Harris
Sep 19, 2002·Analytical Chemistry·Wilder D Smith
Oct 12, 2002·The Analyst·Victor Bocos-BintintanC L Paul Thomas
Dec 31, 2003·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Igor A Buryakov
Nov 24, 2004·Analytical Chemistry·G A Eiceman, J A Stone
Dec 2, 2006·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Yasuo Seto
Jul 31, 2008·Analytical Chemistry·Stefan ZimmermannJoachim Ringer
Sep 2, 2008·Talanta·Jarosław PutonMika Sillanpää
Mar 1, 1994·Journal of the American Society for Mass Spectrometry·S E BellZ Karpas

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Citations

Mar 14, 2018·Critical Reviews in Analytical Chemistry·Zygfryd WitkiewiczJavier Quagliano
Apr 3, 2020·Analytical Chemistry·Brian C HauckVincent M McHugh

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