PMID: 6159005Nov 4, 1980Paper

Ion movements in gramicidin pores. An example of single-file transport

Biochimica Et Biophysica Acta
B W UrbanD A Haydon

Abstract

Experimental results on ion movement through gramicidin membrane channels are presented and discussed in terms of ion transport in the simplest single-file pore (for review see Urban, B.W. and Hladky, S.B. (1979) Biochim. Biophys. Acta 554, 410-429). Single-channel conductance and bi-ionic potential data for Na+, K+, Cs+, NH4+ and Tl+ are used to assign values to the rate constants of the model. Not all of the rate constants can be determined uniquely and simplifications are introduced to reduce the number of free parameters. The simplified model gives good quantitative fits to the experimental results for Na+, K+, Cs+ and NH4+. For Tl+, although the model accounts qualitatively for the salient features of the results, the quantitative agreement is less satisfactory. Predictions calculated from the model and the fitted rate constants are compared with independent data from blocking and tracer-flux measurements. In agreement with experiment, the model shows that only Tl+ blocks the Na+ conductance significantly. Furthermore, the exponent, n, in the tracer flux ratio rises, as observed, well above unity. The values for the rate constants suggest internal consistency of the model in that entry is always slower to singly occupied p...Continue Reading

References

Jan 21, 1976·Biochimica Et Biophysica Acta·E BambergP Läuger
Jan 4, 1977·Biochimica Et Biophysica Acta·E Neher, H Eibl
Jun 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·E BambergH Alpes
Sep 1, 1978·The Journal of General Physiology·P A Rosenberg, A Finkelstein
Jul 5, 1979·Biochimica Et Biophysica Acta·B W Urban, S B Hladky
Jan 1, 1972·The Journal of Membrane Biology·S B Hladky
Aug 9, 1972·Biochimica Et Biophysica Acta·V B Myers, D A Haydon
Aug 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·D W UrryD F Mayers
Jan 1, 1965·Annual Review of Physiology·R P FORSTER

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Citations

Nov 1, 1995·Protein Science : a Publication of the Protein Society·S H LiawD Eisenberg
Mar 1, 1990·The Journal of Membrane Biology·G A Kimmich
Aug 1, 1989·The Journal of Membrane Biology·P Läuger
Jan 1, 1982·The Journal of Membrane Biology·B E Cohen
Jan 1, 1983·The Journal of Membrane Biology·M Parisi, J Bourguet
Feb 4, 2006·The Journal of Membrane Biology·J A Hernández, J Fischbarg
Jun 1, 1996·Pflügers Archiv : European journal of physiology·K MagishiY Abiko
Dec 1, 2007·Journal of Biological Physics·Mario ParisiRoxana Toriano
Nov 1, 1988·Brain Research·D S DuchB W Urban
Oct 14, 2010·The Journal of Physical Chemistry. B·Yuhui LiBenoît Roux
Oct 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·E W McCleskey, W Almers
Mar 7, 1998·The Journal of General Physiology·H A Lester, D A Dougherty
Nov 30, 1999·The Journal of General Physiology·P C Jordan
Aug 29, 2001·The Journal of General Physiology·M LeMasurierC Miller
Jan 1, 1991·Annals of the New York Academy of Sciences·B W UrbanA B Kauff
Dec 10, 2002·Annual Review of Physiology·William A Sather, Edwin W McCleskey
Jun 19, 2001·Biological Chemistry·W van 't HofA V Amerongen
Jul 26, 2014·International Journal of Nanomedicine·Danielle A M T RagiotoAna M Carmona-Ribeiro
Apr 9, 2005·IEEE Transactions on Nanobioscience·Olaf S AndersenBenoît Roux
Jun 8, 2015·The Journal of Chemical Physics·Paul Stevenson, Andrei Tokmakoff
Dec 26, 2003·Biophysical Journal·Gennady V Miloshevsky, Peter C Jordan
Dec 4, 2003·Biophysical Journal·Ekaterina M NestorovichSergey M Bezrukov
Sep 24, 1998·Biophysical Journal·T K RostovtsevaV A Parsegian
Mar 17, 2007·The Journal of Chemical Physics·Turgut Baştuğ, Serdar Kuyucak
Jan 20, 2017·Nano Letters·Hasti AmiriRaúl Hernández Sánchez
Jul 25, 2006·Biophysical Journal·Jacob Devin DurrantDavid D Busath
Apr 19, 2008·Chemistry & Biology·Kristin L HortonShana O Kelley
Feb 20, 2015·Chemical Communications : Chem Comm·Pengyang XinZhan-Ting Li
Sep 15, 2006·Chembiochem : a European Journal of Chemical Biology·Elena A GounPaul A Wender

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