Ion-pair formation of Bi(III)-iodide with some nitrogenous drugs and its application to pharmaceutical preparations

Journal of Pharmaceutical and Biomedical Analysis
F M Abdel-Gawad

Abstract

A systematic spectrophotometric study on the ion-pair formation of Bi(III)-iodide with amineptine hydrochloride, piribedil and trimebutine maleate is carried out. The optimal experimental conditions pH, concentration of Bi(III) nitrate, potassium iodide; and the nature and amount of organic solvent have been studied. The ion pairs are soluble in 1,2-dichloroethane and the optimum pH range is 2.0-2.8. By application of the methods of Sommer and Job involving non-equimolar solutions, the conditional stability constant (log K') of the Bi(III) piridedil ion pair (1:1) at the optimum pH of 2.4 and an ionic strength (mu) 0.1 M, was found to be 5.436. The validity of Beer's law has been tested in the concentration range 5-50 microg ml(-1) in the organic layer, the relative standard deviation is less than 1%. The method is applied to the determination of these drugs in tablets without interference.

References

Sep 1, 1977·The Journal of Pharmacy and Pharmacology·R SamaninS Garattini
Nov 1, 1968·Journal of Medicinal Chemistry·G L RegnierJ C Le Douarec

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Citations

Sep 16, 2003·Journal of Pharmaceutical and Biomedical Analysis·Alaa El-GindyGhada M Hadad
May 7, 2004·Journal of Pharmaceutical and Biomedical Analysis·Suzy M SabryTarek S Belal
Dec 5, 2006·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Ragaa El-ShiekhAyman Abou El-Fetouh Gouda
Apr 29, 2015·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Somayeh Mohammadi, Gholamreza Khayatian

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