Ion-pairs of ibuprofen: increased membrane diffusion

The Journal of Pharmacy and Pharmacology
Vikram SarveiyaH A Benson

Abstract

The purpose of the present study was to determine the influence of pH and ion-pairing on the permeation of ibuprofen across polydimethylsiloxane (PDMS) membrane. The solubility of ibuprofen sodium was determined at a range of pH values. Saturated solutions were then used to determine the influence of pH on diffusion across PDMS as a model membrane. The apparent partition coefficient of ibuprofen sodium between n-octanol and phosphate buffer at various pH values was also investigated. Organic salts of ibuprofen using ethylamine, diethylamine, triethylamine and ethylene diamine as counter-ions were synthesized and the influence of these counter-ions on the permeation of ibuprofen was studied. The presence of ion-pairing was confirmed using 1H NMR and 13C NMR. Diffusion studies at different pH values (4.0, 5.0, 6.0, 7.0 and 8.0) indicated that ibuprofen sodium flux increased significantly with increasing pH from 4.0 to 7.0. Above pH 7.0 a decrease in diffusion was observed. The permeability coefficient increased with an increase in the amount of unionized acid. The apparent partition coefficient was directly related to the steady-state flux. The steady-state flux of ibuprofen increased up to 16-fold using different counter-ions. T...Continue Reading

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Citations

Feb 22, 2012·Advanced Drug Delivery Reviews·Daniela KaradzovskaJim E Riviere
Jul 8, 2014·Therapeutic Delivery·Julia L Shamshina, Robin D Rogers
Jul 12, 2008·Drug Development and Industrial Pharmacy·Xiaochen GuBenjamin R Collins
Jan 1, 2009·Journal of Pharmaceutical Sciences·Vijay D Ivaturi, S Kwonho Kim
Nov 7, 2009·Journal of Pharmaceutical Sciences·Xu MaZhonggui He
Apr 3, 2008·The Journal of Pharmacy and Pharmacology·Manli WangTing Li
Mar 28, 2006·International Journal of Pharmaceutics·S-A KoufopoulouA Tsantili-Kakoulidou
Jun 14, 2005·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Vikram SarveiyaHeather A E Benson
Aug 25, 2016·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Isabel Lozoya-AgulloMarival Bermejo
Jul 18, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Deepak GuptaSheeba Varghese Gupta
Mar 4, 2021·Pharmaceutical Development and Technology·Afrooz HamidehMansoor A Khan
Mar 16, 2021·Journal of Drug Delivery Science and Technology·Sagar NaralaMichael A Repka
Apr 23, 2021·Drug Delivery and Translational Research·Chin-Ping KungRenée McCulloch

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