Ion sampling effects under conditions of total solvent consumption

Rapid Communications in Mass Spectrometry : RCM
Bradley B SchneiderThomas R Covey

Abstract

The motivation of this work was to study some of the properties of nanoelectrospray operation under conditions where the entire sprayed liquid is vaporized and inhaled into the vacuum system. Under these conditions the desolvation requirements, sampling efficiency, concentration versus mass sensitivity, and molar response characteristics of various compounds were studied. The combined efficiency of ion production from solution and transfer into the vacuum system, referred to as sampling efficiency, is presented under various inlet conditions including different flow rates, solution compositions, and compound types. Under ideal solvent conditions the results for favorable compounds show sampling efficiencies of 70-85% at flows in the range of 50-500 nL/min. Efficiencies were lower for aqueous samples and compounds of different structures gave different molar response factors under these high sampling efficiency conditions. The relative molar response factors are presented in terms of those observed with higher flow rate sources which operate at significantly lower sampling efficiencies. In all cases, operating in this flow regime, the ion count rate was directly proportional to the absolute mass of analyte molecules entering the...Continue Reading

References

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Nov 5, 2003·Journal of the American Society for Mass Spectrometry·Bradley B SchneiderThomas R Covey
Jul 28, 2004·Journal of the American Society for Mass Spectrometry·Gary A ValaskovicMike S Lee
Jul 19, 2005·Journal of the American Society for Mass Spectrometry·Bradley B SchneiderThomas R Covey
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Citations

Jul 14, 2007·Journal of the American Society for Mass Spectrometry·Jason S PageRichard D Smith
Mar 29, 2014·Journal of the American Society for Mass Spectrometry·Jonathan T CoxKeqi Tang
Mar 26, 2011·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Pat Wright
Feb 1, 2011·International Journal of Mass Spectrometry·Bradley B SchneiderErkinjon G Nazarov
Mar 4, 2009·Trends in Analytical Chemistry : TRAC·Thomas O MetzRichard D Smith
Jul 25, 2009·Mass Spectrometry Reviews·Thomas R CoveyBradley B Schneider
Dec 1, 2006·Journal of Mass Spectrometry : JMS
Jan 10, 2012·Rapid Communications in Mass Spectrometry : RCM·Jingzhou LiuYohannes Teffera
Jun 4, 2015·Bioanalysis·Shane R Needham, Gary A Valaskovic
Jan 16, 2015·Journal of the American Society for Mass Spectrometry·Andrew N KrutchinskyBrian T Chait
Oct 1, 2014·Journal of the American Society for Mass Spectrometry·Jonathan T CoxKeqi Tang
Apr 19, 2016·Annual Review of Analytical Chemistry·Stephan RauschenbachKlaus Kern
Oct 3, 2012·Analytical Chemistry·Ioan MargineanRichard D Smith
Jun 5, 2014·European Journal of Mass Spectrometry·Petr JurcicekHongbin Xiao
Aug 17, 2019·Journal of the American Society for Mass Spectrometry·Yang KangThomas R Covey
Jul 1, 2017·Journal of the American Society for Mass Spectrometry·Bradley B SchneiderThomas R Covey
Jul 25, 2017·Journal of the American Society for Mass Spectrometry·Yang KangThomas R Covey
Jun 26, 2021·Journal of the American Society for Mass Spectrometry·Zhongbao Han, Lee Chuin Chen
Jan 6, 2021·Journal of the American Society for Mass Spectrometry·Hassan Javaheri, Bradley B Schneider
Oct 30, 2010·Analytical Chemistry·Ioan MargineanRichard D Smith

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