Ion-sensitive in situ hydrogels of natamycin bilosomes for enhanced and prolonged ocular pharmacotherapy: in vitro permeability, cytotoxicity and in vivo evaluation

Artificial Cells, Nanomedicine, and Biotechnology
Karthik Yadav JangaSoumyajit Majumdar

Abstract

Delivery of therapeutic molecules into the deeper ocular compartments is mainly hampered by short precorneal residence and limited transmembrane permeability of topically administered drugs. Hence, the current study was undertaken to fabricate the ion-sensitive in situ gels of natamycin (NT) bilosomes (NB) for efficient ocular delivery. The effect of cholesterol and sodium taurocholate proportion on the properties of the bilosomes were studied and the formulation with better physicochemical properties was optimized and utilized to derive the in situ gelling system (IG). The impact of type/composition of gelling agent on the formation and characteristics of the hydrogel was investigated. The hydrogel formed from IG with 0.3% w/v gellan gum showed optimal viscoelastic and adhesive characteristics. The ocular safety and cytocompatibility of NB and its IG was confirmed by corneal histology and in vitro cytotoxicity evaluation. A 6- to 9-fold enhancement in the transcorneal flux of NB demonstrated efficient ocular penetration of bilosomes. Moreover, the superior mean dose normalized NT levels in the ocular tissues of rabbits treated with optimized NB and IG illustrated the effectiveness of bilosomes loaded ion-sensitive in situ hydr...Continue Reading

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Citations

May 18, 2019·Nanomaterials·Blanca Lorenzo-VeigaCarmen Alvarez-Lorenzo
Apr 22, 2020·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Akash PatilSoumyajit Majumdar
Mar 16, 2019·The Journal of Pharmacology and Experimental Therapeutics·Karthik Yadav JangaSoumyajit Majumdar
Dec 15, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Thangavelu MuthukumarGilson Khang
Apr 4, 2021·Pharmaceuticals·Ahmed Adel Ali YoussefSoumyajit Majumdar
Jul 5, 2021·Ophthalmology and Therapy·Lixiang WangHui Zhang

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