Covering: 2013 The ability to transfer molecular species to the gas phase and ionize them is central to the study of natural products and other molecular species by mass spectrometry (MS). MS-based strategies in natural products have focused on a few established ion sources, such as electron impact and electrospray ionization. However, a variety of other ion sources are either currently in use to evaluate natural products or show significant future promise. This review discusses these various ion sources in the context of other articles in this special issue, but is also applicable to other fields of analysis, including materials science. Ion sources are grouped based on the current understanding of their predominant ion formation mechanisms. This broad overview groups ion sources into the following categories: electron ionization and single photon ionization; chemical ionization-like and plasma-based; electrospray ionization; and, laser desorption-based. Laser desorption-based methods are emphasized with specific examples given for laser desorption postionization sources and their use in the analysis of intact microbial biofilms. Brief consideration is given to the choice of ion source for various sample types and analyses, in...Continue Reading
Fast atom bombardment, electron ionization and chemical ionization mass spectrometry of 1,2,3-benzenetricarboxylic acids, inhibitors of the mitochondrial tricarboxylate carrier
Atmospheric pressure photoionization mass spectrometry. Ionization mechanism and the effect of solvent on the ionization of naphthalenes
Size-selected (2-10 nm) gold nanoparticles for matrix assisted laser desorption ionization of peptides
Determination of single photon ionization cross sections for quantitative analysis of complex organic mixtures
Ambient molecular imaging and depth profiling of live tissue by infrared laser ablation electrospray ionization mass spectrometry
The characterization of selected drugs with infrared laser desorption/tunable synchrotron vacuum ultraviolet photoionization mass spectrometry
Laser desorption 7.87 eV postionization mass spectrometry of antibiotics in Staphylococcus epidermidis bacterial biofilms.
Observation of molecular ions and analysis of nonpolar compounds with the direct analysis in real time ion source
Bioanalysis without sample cleanup or chromatography: the evaluation and initial implementation of direct analysis in real time ionization mass spectrometry for the quantification of drugs in biological matrixes
Atmospheric pressure photoionization for coupling liquid-chromatography to mass spectrometry: a review
Matrix-assisted laser desorption/ionization by using femtosecond laser pulses in the near-infrared wavelength regime
Fixation and drying protocols for the preparation of cell samples for time-of-flight secondary ion mass spectrometry analysis
Recent applications of synchrotron VUV photoionization mass spectrometry: insight into combustion chemistry
Capturing bacterial metabolic exchange using thin film desorption electrospray ionization-imaging mass spectrometry.
Small molecule ambient mass spectrometry imaging by infrared laser ablation metastable-induced chemical ionization
High-spatial and high-mass resolution imaging of surface metabolites of Arabidopsis thaliana by laser desorption-ionization mass spectrometry using colloidal silver
Ambient ionization mass spectrometry: current understanding of mechanistic theory; analytical performance and application areas
Desorption electrospray ionization and other ambient ionization methods: current progress and preview
Analysis of pharmaceutical compounds from glass, fabric, steel, and wood surfaces at atmospheric pressure using spatially resolved, nonresonant femtosecond laser vaporization electrospray mass spectrometry
Internal energies of ion-sputtered neutral tryptophan and thymine molecules determined by vacuum ultraviolet photoionization
Matrix-enhanced secondary ion mass spectrometry (ME SIMS) using room temperature ionic liquid matrices
Laser desorption postionization mass spectrometry of antibiotic-treated bacterial biofilms using tunable vacuum ultraviolet radiation.
MALDI mass spectrometry imaging for the simultaneous location of resveratrol, pterostilbene and viniferins on grapevine leaves
Direct detection of the anti-cancer drug 9-phenylacridine in tissues by graphite rod laser desorption vacuum-ultraviolet post-ionization mass spectrometry
Intraspecific variations in Conus purpurascens injected venom using LC/MALDI-TOF-MS and LC-ESI-TripleTOF-MS
Mass spectrometry in untargeted liquid chromatography/mass spectrometry metabolomics: Electrospray ionisation parameters and global coverage of the metabolome
High-resolution mass spectrometry for future space missions: Comparative analysis of complex organic matter with LAb-CosmOrbitrap and laser desorption/ionization Fourier transform ion cyclotron resonance
Metabolomics of Exhaled Breath Condensate by Nuclear Magnetic Resonance Spectroscopy and Mass Spectrometry: A Methodological Approach
Comparative mass spectrometry-based metabolomics strategies for the investigation of microbial secondary metabolites
Nonuniform Electric Field-Enhanced In-Source Declustering in High-Pressure Photoionization/Photoionization-Induced Chemical Ionization Mass Spectrometry for Operando Catalytic Reaction Monitoring
Spatially Resolved Mass Spectrometry at the Single Cell: Recent Innovations in Proteomics and Metabolomics.
Realization of in-source collision-induced dissociation in single-photon ionization time-of-flight mass spectrometry and its application for differentiation of isobaric compounds
Vacuum-Ultraviolet-Excited and CH2 Cl2 /H2 O-Amplified Ionization-Coupled Mass Spectrometry for Oxygenated Organics Analysis
High lateral resolution vs molecular preservation in near-IR fs-laser desorption postionization mass spectrometry
Kinetic Understanding of the Ultrahigh Ionization Efficiencies (up to 28%) of Excited-State CH2 Cl2 -Induced Associative Ionization: A Case Study with Nitro Compounds
An Experimental and Theoretical Study of Laser Postionization of Femtosecond-Laser-Desorbed Drug Molecules.
Biofilm & Infectious Disease
Biofilm formation is a key virulence factor for a wide range of microorganisms that cause chronic infections.Here is the latest research on biofilm and infectious diseases.