Ion transport, membrane fluidity and haemoglobin conformation in erythrocyte from patients with cardiovascular diseases: Role of augmented plasma cholesterol

Pathophysiology : the Official Journal of the International Society for Pathophysiology
O G LunevaE I Chazov

Abstract

Tissue hypoxia, which plays a key role in the development of renal and vascular complications of cardiovascular diseases (CVD), might be considered a consequence of vascular remodeling and/or attenuated oxygen (O(2)) delivery by erythrocytes. Using Raman spectroscopy (RS), we observed that erythrocytes from patients with CVD exhibit changes in the conformation of haemoglobin (Hb) haemoporphyrin (HP), reflecting its lower O(2) transport capacity. Hypertriglyceridemia and hypercholesterolemia are well-known hallmarks of CVD. This study examined the role of plasma lipids in the regulation of erythrocyte membrane viscosity, oxy-Hb content as well as Na(+)/H(+) exchange and Ca(2+)-ATPase, whose activities are altered in patients with CVD. HP conformation was assessed by RS of blood samples. Membrane fluidity was estimated at depths of 0.6-0.8 and 2.2nm by electron-paramagnetic resonance spectroscopy of erythrocytes loaded with spin-labeled 5-doxylstearic acid and 16-doxylstearic acid, respectively. Ion-selective electrodes were employed for the study of H(+) and Ca(2+) fluxes. Both oxy-Hb content and erythrocyte membrane fluidity were decreased in essential hypertension and coronary artery disease patients and negatively correlated ...Continue Reading

References

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Citations

Sep 17, 2013·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Edyta PytelMarlena Broncel
Feb 21, 2014·Molecular Neurobiology·Xiaoguang YangJames C-M Lee
Mar 26, 2011·Organic & Biomolecular Chemistry·Hyung-Jo YoonEmmanuel A Theodorakis
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Apr 12, 2013·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Jianfang CaoXiaojun Peng
Jun 16, 2015·Frontiers in Neuroscience·Donghui ZhuSholpan Askarova
Oct 13, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Malongil B Reena, B R Lokesh
Dec 17, 2009·Biophysical Journal·Nadezda A BrazheGeorgy V Maksimov
Apr 20, 2005·Pathophysiology : the Official Journal of the International Society for Pathophysiology·O V RodnenkovE I Chazov
Apr 1, 2018·Journal of Biophotonics·Nadezda A BrazheOlga Sosnovtseva
Nov 1, 2019·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Kazushi Tsuda
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Jun 30, 2017·Critical Reviews in Food Science and Nutrition·Fatemah M AlhassawiRichard D Ludescher
Jan 14, 2016·Chemical Communications : Chem Comm·RoopaManoi Kumar

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