Ion transport, membrane fluidity and haemoglobin conformation in erythrocyte from patients with cardiovascular diseases: Role of augmented plasma cholesterol

Pathophysiology : the Official Journal of the International Society for Pathophysiology
O G LunevaE I Chazov


Tissue hypoxia, which plays a key role in the development of renal and vascular complications of cardiovascular diseases (CVD), might be considered a consequence of vascular remodeling and/or attenuated oxygen (O(2)) delivery by erythrocytes. Using Raman spectroscopy (RS), we observed that erythrocytes from patients with CVD exhibit changes in the conformation of haemoglobin (Hb) haemoporphyrin (HP), reflecting its lower O(2) transport capacity. Hypertriglyceridemia and hypercholesterolemia are well-known hallmarks of CVD. This study examined the role of plasma lipids in the regulation of erythrocyte membrane viscosity, oxy-Hb content as well as Na(+)/H(+) exchange and Ca(2+)-ATPase, whose activities are altered in patients with CVD. HP conformation was assessed by RS of blood samples. Membrane fluidity was estimated at depths of 0.6-0.8 and 2.2nm by electron-paramagnetic resonance spectroscopy of erythrocytes loaded with spin-labeled 5-doxylstearic acid and 16-doxylstearic acid, respectively. Ion-selective electrodes were employed for the study of H(+) and Ca(2+) fluxes. Both oxy-Hb content and erythrocyte membrane fluidity were decreased in essential hypertension and coronary artery disease patients and negatively correlated ...Continue Reading


May 29, 1981·Biochemical and Biophysical Research Communications·T Montenay-GarestierC Helene
Apr 1, 1994·European Journal of Biochemistry·V PetrovP Lijnen
May 1, 1996·Free Radical Research·W K SubczynskiJ S Hyde
Oct 18, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Jamie W MeyerGary E Shull
Aug 5, 2004·Pflügers Archiv : European journal of physiology·Yana J AnfinogenovaS N Orlov
Apr 20, 2005·Pathophysiology : the Official Journal of the International Society for Pathophysiology·O V RodnenkovE I Chazov


Sep 17, 2013·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Edyta PytelMarlena Broncel
Feb 21, 2014·Molecular Neurobiology·Xiaoguang YangJames C-M Lee
Mar 26, 2011·Organic & Biomolecular Chemistry·Hyung-Jo YoonEmmanuel A Theodorakis
Jun 16, 2012·Bioorganic & Medicinal Chemistry·Marianna DakanaliEmmanuel A Theodorakis
Jul 14, 2010·The Journal of Nutritional Biochemistry·Roberta CazzolaBenvenuto Cestaro
Aug 10, 2010·Tetrahedron·Jeyanthy SutharsanEmmanuel A Theodorakis
Apr 12, 2013·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Jianfang CaoXiaojun Peng
Jun 16, 2015·Frontiers in Neuroscience·Donghui ZhuSholpan Askarova
Oct 13, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Malongil B Reena, B R Lokesh
Dec 17, 2009·Biophysical Journal·Nadezda A BrazheGeorgy V Maksimov
Apr 20, 2005·Pathophysiology : the Official Journal of the International Society for Pathophysiology·O V RodnenkovE I Chazov
Apr 1, 2018·Journal of Biophotonics·Nadezda A BrazheOlga Sosnovtseva
Nov 1, 2019·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Kazushi Tsuda
Nov 19, 2019·Frontiers in Physiology·Juan Pablo Zuniga-Hertz, Hemal H Patel
Jun 30, 2017·Critical Reviews in Food Science and Nutrition·Fatemah M AlhassawiRichard D Ludescher
Jan 14, 2016·Chemical Communications : Chem Comm·RoopaManoi Kumar

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Glut1 Deficiency

Glut1 deficiency, an autosomal dominant, genetic metabolic disorder associated with a deficiency of GLUT1, the protein that transports glucose across the blood brain barrier, is characterized by mental and motor developmental delays and infantile seizures. Follow the latest research on Glut1 deficiency with this feed.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Nodding Syndrome

Nodding Syndrome is a neurological and epileptiform disorder characterized by psychomotor, mental, and growth retardation. Discover the latest research on Nodding Syndrome here.

LRRK2 & Microtubules

Mutations in the LRRK2 gene are risk-factors for developing Parkinson’s disease (PD). LRRK2 mutations in PD have been shown to enhance its association with microtubules. Here is the latest research.