Ion trap with narrow aperture detection electrodes for Fourier transform ion cyclotron resonance mass spectrometry

Journal of the American Society for Mass Spectrometry
Konstantin O NagornovYury O Tsybin

Abstract

The current paradigm in ion trap (cell) design for Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) is the ion detection with wide aperture detection electrodes. Specifically, excitation and detection electrodes are typically 90° wide and positioned radially at a similar distance from the ICR cell axis. Here, we demonstrate that ion detection with narrow aperture detection electrodes (NADEL) positioned radially inward of the cell's axis is feasible and advantageous for FT-ICR MS. We describe design details and performance characteristics of a 10 T FT-ICR MS equipped with a NADEL ICR cell having a pair of narrow aperture (flat) detection electrodes and a pair of standard 90° excitation electrodes. Despite a smaller surface area of the detection electrodes, the sensitivity of the NADEL ICR cell is not reduced attributable to improved excite field distribution, reduced capacitance of the detection electrodes, and their closer positioning to the orbits of excited ions. The performance characteristics of the NADEL ICR cell are comparable with the state-of-the-art FT-ICR MS implementations for small molecule, peptide, protein, and petroleomics analyses. In addition, the NADEL ICR cell's design improves the flex...Continue Reading

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Citations

Nov 19, 2015·International Journal of Molecular Sciences·Simone NicolardiYuri E M van der Burgt
Jun 6, 2015·Rapid Communications in Mass Spectrometry : RCM·David P A KilgourYury O Tsybin
Aug 27, 2015·European Journal of Mass Spectrometry·Irina A TarasovaMikhail V Gorshkov
Nov 10, 2017·Journal of the American Society for Mass Spectrometry·Konstantin O NagornovYury O Tsybin
Dec 9, 2020·Mass Spectrometry Reviews·Juan D ChavezJames E Bruce
Jan 20, 2021·Mass Spectrometry Reviews·Konstantin O NagornovYury O Tsybin
May 8, 2018·International Journal of Mass Spectrometry·Sung-Gun ParkJames E Bruce
Apr 27, 2021·International Journal of Mass Spectrometry·Sung-Gun ParkJames E Bruce
Jan 7, 2017·Journal of the American Society for Mass Spectrometry·Sung-Gun ParkJames E Bruce
Feb 19, 2017·Journal of the American Society for Mass Spectrometry·Konstantin O NagornovYury O Tsybin
Oct 19, 2017·Journal of the American Society for Mass Spectrometry·Joshua A DriverI Jonathan Amster
Sep 24, 2020·Journal of the American Society for Mass Spectrometry·Konstantin O NagornovYury O Tsybin

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