IoNESCO trial: Immune neoajuvant therapy in early stage non-small cell lung cancer

Revue des maladies respiratoires
X MignardM Wislez

Abstract

Programmed cell death-ligand 1 (PD-L1) is a checkpoint receptor that facilitates immune evasion by tumor cells, through interaction with programmed cell death-1 (PD-1), a receptor expressed by T-cells. Durvalumab is an anti-PD-L1 monoclonal antibody that blocks PD-L1 interaction with PD-1 on T-cells, countering the tumor's immune-evading tactics. Phase I/II studies demonstrated durable responses and manageable tolerability in heavily pre-treated patients with non-small cell lung cancer (NSCLC). This phase II study is designed to administrate three durvalumab IV infusions (10mg/kg at day 1, 15, 29) before surgery, to patients with pathologically confirmed NSCLC, clinical stage IB (>4cm) or stage II, ≥18 years of age, WHO performans status 0-1, without selection on PD-L1 expression. Preoperative chemotherapy and radiation therapy are not permitted. The primary objective is feasibility of complete surgical resection. Major pathological response on surgical tissue, defined as 10% or less remaining tumor cells, will be a secondary objective. Additional secondary objectives include tolerance, adverse effects, delay between start of treatment and surgery, response rate (RECIST 1.1), metabolic response rate, postoperative adverse event...Continue Reading

Citations

Feb 23, 2019·Journal of Applied Clinical Medical Physics·Pranshu MohindraJay Burmeister
Jun 5, 2021·Journal for Immunotherapy of Cancer·Elizabeth AhernBrett G M Hughes
Aug 28, 2021·Cancers·Dirk StefaniClemens Aigner

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