Ionic basis of pacemaker generation in dog colonic smooth muscle.

The Journal of Physiology
C Barajas-LópezJ D Huizinga

Abstract

1. The ionic basis of the slow waves in the circular muscle of the dog colon, in particular the ionic conductances involved in their initiation, were investigated by measuring intracellular electrical activity in the Abe-Tomita-type chamber for voltage control. 2. The depolarization that initiates the slow wave activity could be evoked by an increase in inward current and/or by a block of outward current. According to previous work, inward current could be carried by Na+, Cl-, and Ca2+ ions; K+ ions would carry outward current. 3. The Na+ channel blocker tetrodotoxin (5 x 10(-7) M) did not affect the slow wave amplitude nor its rate of rise. After omission of Na+, by replacing Na+ with N-methyl-D-glucamine, large slow waves continued to develop although some changes in slow wave characteristics occurred. 4. Replacement of 91% of the Cl- by isethionate decreased the slow wave frequency and increased the slow wave amplitude. However, NaCl substitution by sucrose increased the slow wave frequency and decreased the slow wave amplitude. 5. Slow wave activity continued to develop after blockade of Ca2+ influx by D600 (10(-6) M) or CoCl2 (1-3 mM). D600 and Co2+ did not affect the membrane potential but reduced the slow wave amplitude ...Continue Reading

Citations

Aug 1, 1995·Pflügers Archiv : European journal of physiology·Z XiongC Fenoglio-Preiser
Feb 1, 1991·Acta Physiologica Scandinavica·M L Lydrup, P Hellstrand
Oct 16, 2015·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·A BeyderG Farrugia
Jan 28, 2012·Therapeutic Advances in Gastroenterology·Arthur Beyder, Gianrico Farrugia
Nov 24, 2017·American Journal of Physiology. Gastrointestinal and Liver Physiology·Peter R StregeGianrico Farrugia
Apr 27, 2002·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·A RichG Farrugia
Jun 1, 1993·Pflügers Archiv : European journal of physiology·Z XiongC Fenoglio-Preiser
Feb 27, 2007·American Journal of Physiology. Gastrointestinal and Liver Physiology·E AlbertíM Jiménez
Jul 18, 2015·American Journal of Physiology. Gastrointestinal and Liver Physiology·Leila NeshatianGianrico Farrugia
Dec 17, 2016·American Journal of Physiology. Gastrointestinal and Liver Physiology·John MalyszGianrico Farrugia
Sep 1, 1993·The American Journal of Physiology·Z XiongC Fenoglio-Preiser
Jul 1, 1992·The American Journal of Physiology·K D ThornburyK M Sanders
Sep 1, 1992·The American Journal of Physiology·J M Post, J R Hume
Sep 1, 1990·The American Journal of Physiology·E P Burke, K M Sanders
Oct 1, 1993·Pharmacology & Therapeutics·F De PontiG Frigo

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