Ionic channels and neuropathic pain: physiopathology and applications

Journal of Cellular Physiology
Caterina AurilioManlio Barbarisi

Abstract

Neuropathic pain is defined by the International Association for Pain research as a pain associated to a primary lesion or a dysfunction of the central or peripheral system. Over the past few years the causes of the neuropathic pain were not known and there were not good treatments for it, now we have a better knowledge of the physiopathological aspects and there is a wider diffusion of the research for target aimed therapies. The physiologic genesis of nervous messages occurs exclusively in skin sensorial endings or in nerve tissues as a consequence of an adequate sensorial stimulus and depends on the quick variations of the electric potential difference at the endings of ionic membranes. These variations of even 500 V a second are possible because of the presence of ionic channels. In neuropathic pain impulses can be originated even from ectopic sites. Ectopic discharges originated in a peripheral neuropathic system have an important role in the early stage of neuropathic pain development in two different ways. First they give an excess of spontaneous and evoked electric impulses to the central nervous system, causing a primitive neuropathic pain signal; then the ectopic activity develops and maintains the central sensitisati...Continue Reading

References

Jan 1, 1995·Annual Review of Pharmacology and Toxicology·G P Miljanich, J Ramachandran
Jan 8, 1998·British Journal of Pharmacology·N A Calcutt, S R Chaplan
Dec 10, 1998·JAMA : the Journal of the American Medical Association·M BackonjaE Garofalo
Dec 10, 1998·JAMA : the Journal of the American Medical Association·M RowbothamL Magnus-Miller
Mar 29, 2001·European Journal of Pharmacology·E A Matthews, A H Dickenson
Jan 24, 2006·The Journal of Pain : Official Journal of the American Pain Society·Marshall Devor
Jan 24, 2006·The Journal of Pain : Official Journal of the American Pain Society·Nadine Attal, Didier Bouhassira

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Citations

Jun 16, 2010·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·David ParrisIan Carroll
May 14, 2011·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Sanjeev KumarElie J Chidiac
Apr 28, 2009·Pharmacology & Therapeutics·Toshihiro DohiNorimitsu Morioka
Feb 27, 2010·The American Journal of Hospice & Palliative Care·Tanmay H Shah, Abdolali Moradimehr
May 11, 2017·Journal of Cellular Physiology·Maria Caterina PaceCaterina Aurilio
Nov 15, 2018·Pharmaceuticals·David J Kopsky, Jan M Keppel Hesselink
Apr 24, 2009·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Dorothée NashanIngrid Gralow
Dec 14, 2012·Expert Review of Neurotherapeutics·Gonzalo Barraza-SandovalJosep Valls-Solé
Jun 23, 2012·Pharmacological Reviews·Anne Estrup OlesenAsbjørn Mohr Drewes
Nov 7, 2008·Expert Review of Neurotherapeutics·Kewal K Jain
Nov 29, 2016·BioMed Research International·Eun Yeong Lim, Yun Tai Kim
Nov 18, 2008·Neurosurgery Clinics of North America·Gavin A Davis, Simon R Knight
May 14, 2009·Current Opinion in Supportive and Palliative Care

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