PMID: 9204Jun 21, 1976

Ionic control of biochemical reactions

Comptes rendus hebdomadaires des séances de l'Académie des sciences. Série D: Sciences naturelles
P Douzou, P Maurel


It is shown that pH and ionic strength are tightly interdependent in cytochrome oxidase activity at the level of inner membranes of the mitochondrion, as a direct consequence of the polyanionic environment of this enzyme. Application of polyelectrolyte theory explains a number of biochemical reactions controlled by ionic strength fluctuations.


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Related Concepts

Cytochrome c Group
Cytochrome c Oxidase Subunit VIa
Hydrogen-Ion Concentration
Ion Exchange
Mitochondria, Liver
Protein Conformation

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