Ionic current inversion in pressure-driven polymer translocation through nanopores

Physical Review Letters
Sahin BuyukdagliT Ala-Nissila

Abstract

We predict streaming current inversion with multivalent counterions in hydrodynamically driven polymer translocation events from a correlation-corrected charge transport theory including charge fluctuations around mean-field electrostatics. In the presence of multivalent counterions, electrostatic many-body effects result in the reversal of the DNA charge. The attraction of anions to the charge-inverted DNA molecule reverses the sign of the ionic current through the pore. Our theory allows for a comprehensive understanding of the complex features of the resulting streaming currents. The underlying mechanism is an efficient way to detect DNA charge reversal in pressure-driven translocation experiments with multivalent cations.

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Citations

Mar 5, 2016·The Journal of Chemical Physics·Sahin Buyukdagli, T Ala-Nissila
Dec 24, 2015·The Journal of Chemical Physics·Malihe GhodratRudolf Podgornik
Sep 12, 2015·The Journal of Physical Chemistry. B·Guang Chen, Siddhartha Das
Mar 15, 2019·Physical Chemistry Chemical Physics : PCCP·Cheng LianJianzhong Wu
Jan 15, 2016·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Zhi-Yong WangYu-Qiang Ma
Jul 1, 2016·Journal of Physics. Condensed Matter : an Institute of Physics Journal·S Buyukdagli, R Blossey
Apr 10, 2019·Polymers·Sahin BuyukdagliTapio Ala-Nissila
Oct 8, 2015·Journal of Physics. Condensed Matter : an Institute of Physics Journal·Sahin Buyukdagli
Feb 24, 2021·Physical Chemistry Chemical Physics : PCCP·Sanjin MarionAleksandra Radenovic
Mar 24, 2021·The Journal of Chemical Physics·S Mohammad HoseinpoorBae-Yeun Ha
Nov 25, 2020·The Journal of Physical Chemistry. B·Sahin Buyukdagli

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