Ionic currents and electromotility in inner ear hair cells from humans

Journal of Neurophysiology
John S OghalaiWilliam E Brownell

Abstract

The upright posture and rich vocalizations of primates place demands on their senses of balance and hearing that differ from those of other animals. There is a wealth of behavioral, psychophysical, and CNS measures characterizing these senses in primates, but no prior recordings from their inner ear sensory receptor cells. We harvested human hair cells from patients undergoing surgical removal of life-threatening brain stem tumors and measured their ionic currents and electromotile responses. The hair cells were either isolated or left in situ in their sensory epithelium and investigated using the tight-seal, whole cell technique. We recorded from both type I and type II vestibular hair cells under voltage clamp and found four voltage-dependent currents, each of which has been reported in hair cells of other animals. Cochlear outer hair cells demonstrated electromotility in response to voltage steps like that seen in rodent animal models. Our results reveal many qualitative similarities to hair cells obtained from other animals and justify continued investigations to explore quantitative differences that may be associated with normal or pathological human sensation.

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Citations

Sep 21, 2004·Current Opinion in Otolaryngology & Head and Neck Surgery·John S Oghalai
Jun 15, 2007·Gene Therapy·B W KesserJ R Holt
Jan 29, 2000·The Annals of Otology, Rhinology, and Laryngology·J S OghalaiW E Brownell
Nov 29, 2007·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Gentiana I WenzelJohn S Oghalai
Jun 20, 2014·Journal of the Association for Research in Otolaryngology : JARO·Rebecca LimAlan M Brichta
Jan 16, 2008·Physiological Reviews·Jonathan Ashmore
Apr 7, 2017·The Journal of Physiology·Alberto Recio-Spinoso, John S Oghalai
Jun 10, 2005·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Karin HotchkissBernd Sokolowski
Mar 21, 2019·Frontiers in Cell and Developmental Biology·Cristiana MatteiMirella Dottori
May 29, 2008·Journal of the Association for Research in Otolaryngology : JARO·Anping XiaJohn S Oghalai
Nov 30, 2004·Hearing Research·John S Oghalai
Jul 29, 2021·Cell and Tissue Research·Farideh MoeinvaziriHossein Baharvand
May 1, 2010·Hearing Research·Anthony W Peng, Anthony J Ricci

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