Ionic currents and ion channels of lobster olfactory receptor neurons.

The Journal of General Physiology
T S McClintock, B W Ache

Abstract

The role of the soma of spiny lobster olfactory receptor cells in generating odor-evoked electrical signals was investigated by studying the ion channels and macroscopic currents of the soma. Four ionic currents; a tetrodotoxin-sensitive Na+ current, a Ca++ current, a Ca(++)-activated K+ current, and a delayed rectifier K+ current, were isolated by application of specific blocking agents. The Na+ and Ca++ currents began to activate at -40 to -30 mV, while the K+ currents began to activate at -30 to -20 mV. The size of the Na+ current was related to the presence of a remnant of a neurite, presumably an axon, and not to the size of the soma. No voltage-dependent inward currents were observed at potentials below those activating the Na+ current, suggesting that receptor potentials spread passively through the soma to generate action potentials in the axon of this cell. Steady-state inactivation of the Na+ current was half-maximal at -40 mV. Recovery from inactivation was a single exponential function that was half-maximal at 1.7 ms at room temperature. The K+ currents were much larger than the inward currents and probably underlie the outward rectification observed in this cell. The delayed rectifier K+ current was reduced by GTP-...Continue Reading

Citations

Nov 2, 2013·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Tizeta TadesseManfred Schmidt
Feb 22, 1991·Proceedings. Biological Sciences·J W Lynch, P H Barry
Apr 15, 2006·Physiological Genomics·Ruben StepanyanTimothy S McClintock
Sep 24, 1998·Journal of Neurophysiology·F S Corotto, W C Michel
Apr 30, 1998·Physiological Reviews·D Schild, D Restrepo
Nov 6, 2007·The Journal of Experimental Biology·Jorge Cebada, Ubaldo García

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