Ionic liquid-derived blood-compatible composite membranes for kidney dialysis.

Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Saravanababu MurugesanRobert J Linhardt

Abstract

A novel heparin- and cellulose-based biocomposite is fabricated by exploiting the enhanced dissolution of polysaccharides in room temperature ionic liquids (RTILs). This represents the first reported example of using a new class of solvents, RTILs, to fabricate blood-compatible biomaterials. Using this approach, it is possible to fabricate the biomaterials in any form, such as films or membranes, fibers (nanometer- or micron-sized), spheres (nanometer- or micron-sized), or any shape using templates. In this work, we have evaluated a membrane film of this composite. Surface morphological studies on this biocomposite film showed the uniformly distributed presence of heparin throughout the cellulose matrix. Activated partial thromboplastin time and thromboelastography demonstrate that this composite is superior to other existing heparinized biomaterials in preventing clot formation in human blood plasma and in human whole blood. Membranes made of these composites allow the passage of urea while retaining albumin, representing a promising blood-compatible biomaterial for renal dialysis, with a possibility of eliminating the systemic administration of heparin to the patients undergoing renal dialysis.

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Citations

May 8, 2013·Carbohydrate Polymers·Ivan Simkovic
Feb 23, 2013·ACS Applied Materials & Interfaces·Elena HeisterAlan B Dalton
Aug 19, 2007·Proceedings of the National Academy of Sciences of the United States of America·Victor L PushparajPulickel M Ajayan
Oct 18, 2007·Journal of Biomaterials Science. Polymer Edition·Pedro Galvan-GarciaMario I Romero
Jun 30, 2010·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Henry T Peng
Nov 22, 2011·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Venkat ShankarramanPaul F McDonagh
Jul 18, 2008·Electrophoresis·Nicola VolpiRobert J Linhardt
Oct 22, 2008·Chemical Communications : Chem Comm·Tae-Joon ParkRobert J Linhardt
Jun 3, 2021·Materials·Aziz EftekhariMohammad Hasanzadeh
Jun 30, 2015·Chemical Reviews·Angeles FarránRobert J Linhardt

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