PMID: 8606366Nov 1, 1995Paper

Ionic mechanisms involved in the regulation of insulin secretion by muscarinic agonists

The Journal of Membrane Biology
S BordinI Atwater

Abstract

The effects of the muscarinic agonist oxotremorine-m (oxo-m) on insulin secretion, K(+)-permeability and electrical activity from isolated mouse pancreatic islets were studied. Oxo-m potentiated glucose-induced insulin secretion in a dose-dependent manner, saturating at ca. 10 microM. At 11.2 mM glucose, oxo-m (0.1 and 10 microM) had two distinct effects on beta-cell electrical activity. Both concentrations increased the steady-state burst frequency, however, at 10 microM an initial and transient polarization was measured, and the subsequent activity was accompanied by a slight depolarization. The polarizing effect of oxo-m was almost completely suppressed by charybdotoxin (ChTX), a blocker of the large conductance (maxi) [Ca2+]i-activated potassium channel (K(Ca)). In the presence of 11.2 mM glucose, oxo-m (50 microM) provoked a significant and transient increase in the 86Rb efflux from perifused islets. This effect was inhibited by ChTX. ChTX also potentiated oxo-m stimulated insulin secretion in the presence of glucose. Finally, the balance between the polarizing and depolarizing effects of oxo-m was variable in different islets and depended on glucose concentration. Insulin secretion stimulated by oxo-m in the presence of g...Continue Reading

Citations

Feb 3, 2011·European Journal of Applied Physiology·Claudio C ZoppiAntonio C Boschero
Aug 6, 2004·Bulletin of Mathematical Biology·Richard Bertram, Arthur Sherman
May 30, 1997·European Journal of Pharmacology·S BordinA C Boschero
May 12, 1998·The Journal of Physiology·J A KozakD E Logothetis
Feb 20, 2016·Metabolism: Clinical and Experimental·Jean Franciesco VettorazziEverardo Magalhães Carneiro
Dec 19, 2006·European Journal of Pharmacology·Sabrina GrassiolliPaulo Cezar de Freitas Mathias
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