PMID: 1200148Nov 1, 1975Paper

Ionic mechanisms of intestinal electrical control activity

The American Journal of Physiology
T Y El-Sharkaway, E E Daniel

Abstract

The effects of inhibition and stimulation of the electrogenic Na pump and of altering the ionic environment on the electrical control activity (ECA) were studied in rabbit jejunal smooth muscle. Pump inhibition abolished the ECA at a time when the membrane potential was more negative than the peak depolarization of the control potential (CP). Pump stimulation hyperpolarized the membrane and CP's appeared. Their amplitude was initially small and progressively increased as the hyperpolarization subsided. Lowering external Na to 20 mM or Ca withdrawal, but not addition of verapamil, reversibly abolished the ECA. Chloride replacement by propionate, isethionate, or benzene-sulphonate caused a transient augmentation, followed by suppression of the secondary depolarization of the CP's and decreased their frequency. The initial depolarization of the CP was little affected. Nitrate substitution increased CP frequency and spiking activity but had no observable effects on the CP configuration. These results suggest that the intestinal control potential may result from conductance changes initially to Na and later to C1 rather than fron an oscillatory electrogenic pump.

Citations

Sep 1, 1979·Pflügers Archiv : European journal of physiology·E Zelcer
Jun 10, 2003·The Journal of Physiology·G D S Hirst, S M Ward
Oct 16, 2015·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·A BeyderG Farrugia
Oct 16, 2016·American Journal of Physiology. Gastrointestinal and Liver Physiology·Mei Hong ZhuKenton M Sanders
Dec 16, 1998·The Journal of Physiology·E J DickensT Tomita
Oct 16, 2004·American Journal of Physiology. Gastrointestinal and Liver Physiology·Geoffrey Boddy, E E Daniel
Aug 11, 2006·Canadian Journal of Physiology and Pharmacology·Geoffrey BoddyE E Daniel
Sep 8, 2006·Digestive Diseases and Sciences·Jieyun YinJ D Z Chen
Sep 2, 2011·American Journal of Physiology. Cell Physiology·Rose Ellen DixonSean M Ward
Aug 26, 1976·The Journal of Membrane Biology·E E DanielM Oki
Feb 10, 1999·The American Journal of Physiology·M JiménezE E Daniel
Dec 17, 2016·American Journal of Physiology. Gastrointestinal and Liver Physiology·John MalyszGianrico Farrugia
Feb 12, 2017·Advances in Physiology Education·Bernard T Drumm, Salah A Baker
Mar 21, 1998·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·H B MikkelsenL Thuneberg
Jan 12, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·Cristian SevcencuHans Gregersen
May 1, 1983·The American Journal of Physiology·K M Sanders
Sep 1, 1987·The American Journal of Physiology·C R Scheid
Sep 1, 1992·The American Journal of Physiology·J M Post, J R Hume

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.