Ionic mechanisms of intrinsic oscillations in neurons of the basolateral amygdaloid complex

Journal of Neurophysiology
H C Pape, R B Driesang

Abstract

Ionic mechanisms underlying low-threshold (LTO) and high-threshold (HTO) oscillations occurring in a class of spiny neurons within the basolateral amygdaloid complex (see companion paper) were investigated in slice preparations of the guinea pig amygdala in vitro. LTOs were abolished through local application of tetrodotoxin (TTX, 10-20 microM) or a decrease in the extracellular sodium concentration ([Na+]o) from 153 to 26 mM, whereas HTOs were more readily elicited under these conditions. The effects of TTX and low [Na+]o were accompanied by a hyperpolarizing shift of the membrane potential by 3 +/- 1 mV and a decrease in apparent input resistance by 14 +/- 11 MOmega. LTOs were not observed during intracellular recording with QX 314 (50 microM) or Cs-acetate (2 M) containing micropipettes. At membrane potentials associated with LTO generation, voltage responses to sinusoidal current input with changing frequency between 0 and 10 Hz were characterized by a peak in the response (resonance) at 2.4 +/- 1 Hz, largely corresponding to the frequency range of the LTOs. Resonance behavior was evident as a peak in the impedance amplitude plot (ZA-plot) and a maximum in the fast Fourier transformation (FFT). Resonance and LTOs were conco...Continue Reading

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Citations

Oct 13, 2000·The European Journal of Neuroscience·A Urbani, O Belluzzi
Nov 27, 2002·The Journal of General Physiology·Jacopo Magistretti, Angel Alonso
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