Ionic requirements for taurocholate transport in rat liver plasma membrane vesicles

Journal of Bioenergetics and Biomembranes
F A SimionS Fleischer

Abstract

As part of the enterohepatic circulation, taurocholate is taken up by hepatocytes by a Na+-gradient-dependent, carrier-mediated process. The dependence of taurocholate uptake on the presence of a Na+ gradient, outside greater than inside, has been studied in isolated rat liver plasma membranes. The uptake is specific for sodium, and a cotransport stoichiometry of 2 Na+ per taurocholate taken up was found. The presence of K+ ions inside the vesicles was also found to be essential for maximum Na+-stimulated uptake of taurocholate, although a K+ gradient is not required. Mg2+ was almost as effective as K+ in this regard. The symport of Na+ and taurocholate during uptake was shown to be electrogenic, so that K+ may act as an exchange counterion preventing the accumulation of positive charge within the vesicles.

References

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Citations

Jan 1, 1989·Experimental Pathology·L Camogliano, A Casu
Feb 24, 1988·Biochimica Et Biophysica Acta·M Frimmer, K Ziegler

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