PMID: 1200138Nov 1, 1975Paper

Ionic requirements of proximal tubular sodium transport. I. Bicarbonate and chloride

The American Journal of Physiology
R Green, G Giebisch

Abstract

Simultaneous perfusion of peritubular capillaries and proximal convoluted tubules was used to study the effect of varying transepithelial ionic gradients on ionic fluxes. Results show that net sodium influx and volume flux was one-third of normal when bicarbonate was absent, no chloride gradient existed, and glucose and amino acids were absent. Addition of bicarbonate to the luminal fluid did not restore the flux to normal, but peritubular bicarbonate did restore it. A chloride gradient imposed when no bicarbonate was present could only increase the fluxes slightly, but his flux was significant even after cyanide had poisoned transport. Reversing the chloride concentration gradient decreased the net sodium and volume fluxes whether bicarbonate was present or not. Glucose had no effect on fluxes, but substitution of Na by choline abolished them entirely. It is concluded that sodium is actively transported, that a chloride concentration gradient from lumen to plasma could account for up to 20% of net transport, and that peritubular bicarbonate is necessary for normal rates of sodium and fluid absorption.

Citations

Jan 1, 1981·The Journal of Membrane Biology·A EdelmanT Anagnostopoulos
Jan 1, 1982·The Journal of Membrane Biology·E J WeinmanH O Senekjian
Nov 1, 1976·Scandinavian Journal of Clinical and Laboratory Investigation·O MathisenF Kiil
Apr 1, 1986·Clinical and Experimental Pharmacology & Physiology·J ZhuoS L Skinner
Dec 1, 1980·Pflügers Archiv : European journal of physiology·B CormanC de Rouffignac
Jan 12, 2001·Physiological Reviews·S Muto
Apr 25, 1977·Pflügers Archiv : European journal of physiology·K J UllrichS Klöss
Jan 1, 1987·The Journal of Membrane Biology·P S Steels, E L Boulpaep
Dec 1, 1983·Pflügers Archiv : European journal of physiology·A C CassolaE Frömter
Oct 1, 1982·Pflügers Archiv : European journal of physiology·S W WeinsteinL Moore
Jan 1, 1980·Annals of the New York Academy of Sciences·R GreenG Giebisch
Nov 1, 1978·Scandinavian Journal of Clinical and Laboratory Investigation·O MathisenF Kiil
Jan 1, 1986·Pflügers Archiv : European journal of physiology·L SchildP S Aronson
Apr 1, 1983·Pflügers Archiv : European journal of physiology·B Corman, A Di Stefano
Aug 10, 2010·Annual Review of Physiology·Gerhard H Giebisch
Feb 1, 1982·The American Journal of Medicine·M G Cogan
Aug 1, 1986·Kidney International·G A Quamme, J H Dirks

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