PMID: 909Nov 1, 1975

Ionic requirements of proximal tubular sodium transport. II. Hydrogen ion

The American Journal of Physiology
R Green, G Giebisch


Simultaneous perfusion to proximal convoluted tubules and peritubular capillaries was used to study the effects of different perfusion fluids on sodium reabsorption and hydrogen secretion, which was calculated as bicarbonate reabsorption and titratable acid. Results show that sodium reabsorption was not tightly coupled to hydrogen secretion. Bicarbonate stimulates both sodium reabsorption and hydrogen secretion, but Tris stimulates only sodium reabsorption. Imposing an adverse chloride gradient across the proximal tubule (C1- peritubular greater than C1- luminal) decreased sodium reabsorption but did not diminish hydrogen secretion. Diamox inhibited both net sodium and hydrogen transport. It is concluded that there is not firm linkage between sodium reabsorption and hydrogen secretion and that bicarbonate probably stimulates sodium transport by a number of mechanisms, including an effect on the sodium transport unrelated to its ability to increase hydrogen ion secretion.


Jan 1, 1986·Pflügers Archiv : European journal of physiology·L SchildP S Aronson
Jan 1, 1981·The Journal of Membrane Biology·V L Costa SilvaG Giebisch
Feb 1, 1978·Scandinavian Journal of Clinical and Laboratory Investigation·O MathisenF Kiil
Dec 1, 1980·Pflügers Archiv : European journal of physiology·B CormanC de Rouffignac
Apr 25, 1977·Pflügers Archiv : European journal of physiology·K J UllrichS Klöss
Aug 10, 2010·Annual Review of Physiology·G Giebisch
Jan 1, 1981·The Journal of Membrane Biology·A EdelmanT Anagnostopoulos
Jan 1, 1979·The American Journal of Physiology·M H Humphreys, L Y Chou

Related Concepts

Carbonic Acid Ions
Depression, Chemical
Hydrogen-Ion Concentration
Kidney Tubules, Proximal

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