Ionized calcium measurements are influenced by albumin--should ionized calcium be corrected?

Scandinavian Journal of Clinical and Laboratory Investigation
Trine R LarsenSteen Antonsen

Abstract

Measurement of ionized calcium (CaI) has been reported to be dependent on albumin concentration. We examined the correlation between albumin and CaI measured on different ion selective electrode analyzers and in different groups of patients in a large dataset, extracted from the laboratory information system. In 17,281 outpatients and 16,194 inpatients, significantly positive correlations were found between CaI and albumin, with changes in CaI per 10 g/L change in albumin ranging from 0.007-0.043 mmol/L and 0.017-0.028 mmol/L, respectively. Correlations were found to be significantly different when using different analyzers. In order to examine whether the difference in correlations between the analyzers were really due to different patient populations investigated on the different analyzers, data analyzed on the same type of analyzer from inpatients from four different wards (intensive care unit, medical ward, surgical ward and orthopedic ward) were examined. There was no significant difference in correlations between patients from the four wards. Although, these results points towards technical causes behind the observed differences it cannot be entirely ruled out that clinical diseases or treatment might influence albumin in...Continue Reading

References

Jun 1, 1978·The Journal of Clinical Endocrinology and Metabolism·J H LadensonJ C Boyd
Apr 29, 1978·British Medical Journal·S C ConceicaoD N Kerr
Dec 13, 1975·British Medical Journal·R W PainB M Duncan
Jun 1, 1989·Scandinavian Journal of Clinical and Laboratory Investigation·B GougetA Truchaud
Jul 1, 1987·Annals of Clinical Biochemistry·R B Payne, D P Jones
Jul 30, 1986·Clinica Chimica Acta; International Journal of Clinical Chemistry·R FreaneyF P Muldowney
Dec 15, 1973·British Medical Journal·R B PayneJ R Milner
Sep 1, 1972·Clinica Chimica Acta; International Journal of Clinical Chemistry·F Lindgärde
Dec 1, 1971·Clinica Chimica Acta; International Journal of Clinical Chemistry·D H Orrell
Jan 1, 1983·Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum·J ThodeO Siggaard-Andersen
Sep 1, 1983·Annals of Clinical Biochemistry·J ThodeO Siggaard-Andersen
Jan 25, 2008·Journal of the American Society of Nephrology : JASN·Laura M Calvi, David A Bushinsky
Jan 1, 1979·The Journal of Automatic Chemistry·P Ferreira, A M Bold
Jan 18, 2011·Clinica Chimica Acta; International Journal of Clinical Chemistry·Geoffrey S Baird

Citations

Mar 27, 2019·Clinical Chemistry·Joel D SmithHans G Schneider
May 24, 2020·The Journal of Applied Laboratory Medicine·Ernie YapPhilip Goldwasser

Related Concepts

Albumins
Calcium
Ions
Retrospective Studies
Ion-Selective Electrodes
Albumins
Calcium
Intensive Care Unit
Laboratory
Ionized calcium

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Synthetic Genetic Array Analysis

Synthetic genetic arrays allow the systematic examination of genetic interactions. Here is the latest research focusing on synthetic genetic arrays and their analyses.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Computational Methods for Protein Structures

Computational methods employing machine learning algorithms are powerful tools that can be used to predict the effect of mutations on protein structure. This is important in neurodegenerative disorders, where some mutations can cause the formation of toxic protein aggregations. This feed follows the latests insights into the relationships between mutation and protein structure leading to better understanding of disease.

Congenital Hyperinsulinism

Congenital hyperinsulinism is caused by genetic mutations resulting in excess insulin secretion from beta cells of the pancreas. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Epigenetic Memory

Epigenetic memory refers to the heritable genetic changes that are not explained by the DNA sequence. Find the latest research on epigenetic memory here.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Femoral Neoplasms

Femoral Neoplasms are bone tumors that arise in the femur. Discover the latest research on femoral neoplasms here.