Ionizing radiation enhances adenoviral vector expressing mda-7/IL-24-mediated apoptosis in human ovarian cancer.

Journal of Cellular Physiology
Luni EmdadPaul B Fisher

Abstract

Ovarian cancer is the fifth most common cause of cancer-related death in women. Current interventional approaches, including debulking surgery, chemotherapy, and/or radiation have proven minimally effective in preventing the recurrence and/or mortality associated with this malignancy. Subtraction hybridization applied to terminally differentiating human melanoma cells identified melanoma differentiation associated gene-7/interleukin-24 (mda-7/IL-24), whose unique properties include the ability to selectively induce growth suppression, apoptosis, and radiosensitization in diverse cancer cells, without causing any harmful effects in normal cells. Previously, it has been shown that adenovirus-mediated mda-7/IL-24 therapy (Ad.mda-7) induces apoptosis in ovarian cancer cells, however, the apoptosis induction was relatively low. We now document that apoptosis can be enhanced by treating ovarian cancer cells with ionizing radiation (IR) in combination with Ad.mda-7. Additionally, we demonstrate that mda-7/IL-24 gene delivery, under the control of a minimal promoter region of progression elevated gene-3 (PEG-3), which functions selectively in diverse cancer cells with minimal activity in normal cells, displays a selective radiosensitiz...Continue Reading

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Citations

Jul 9, 2010·Anti-cancer Drugs·Paul DentPaul B Fisher
Feb 6, 2007·Molecular Cancer·Began GopalanRajagopal Ramesh
Sep 9, 2008·Expert Opinion on Biological Therapy·Robert EagerJohn Nemunaitis
May 5, 2007·Expert Opinion on Biological Therapy·Devanand SarkarPaul B Fisher
Sep 18, 2012·Cytokine & Growth Factor Reviews·Erin L WhitakerPenelope J Duerksen-Hughes
Aug 25, 2010·Pharmacology & Therapeutics·Paul DentPaul B Fisher
May 7, 2020·Cancers·Jian GaoAnja Ehrhardt
Aug 10, 2017·Frontiers in Oncology·Sean M O'CathailMaria A Hawkins
Nov 28, 2013·Cancer Research·Rupesh DashPaul B Fisher
Sep 28, 2021·Applied Microbiology and Biotechnology·Jian ZhangDongzhi Wei
Oct 12, 2010·Cytokine & Growth Factor Reviews·Rupesh DashPaul B Fisher

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