Ionizing Radiation-Induced Immune and Inflammatory Reactions in the Brain

Frontiers in Immunology
Katalin LumniczkyGéza Sáfrány

Abstract

Radiation-induced late brain injury consisting of vascular abnormalities, demyelination, white matter necrosis, and cognitive impairment has been described in patients subjected to cranial radiotherapy for brain tumors. Accumulating evidence suggests that various degrees of cognitive deficit can develop after much lower doses of ionizing radiation, as well. The pathophysiological mechanisms underlying these alterations are not elucidated so far. A permanent deficit in neurogenesis, chronic microvascular alterations, and blood-brain barrier dysfunctionality are considered among the main causative factors. Chronic neuroinflammation and altered immune reactions in the brain, which are inherent complications of brain irradiation, have also been directly implicated in the development of cognitive decline after radiation. This review aims to give a comprehensive overview on radiation-induced immune alterations and inflammatory reactions in the brain and summarizes how these processes can influence cognitive performance. The available data on the risk of low-dose radiation exposure in the development of cognitive impairment and the underlying mechanisms are also discussed.

References

Aug 1, 1991·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·P L McGeerH Akiyama
Oct 1, 1991·The British Journal of Radiology·N V LjubimovaL Kh Eidus
Oct 15, 1995·International Journal of Radiation Oncology, Biology, Physics·J H HongW H McBride
Oct 1, 1995·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D P WaberM Schiller
Jan 1, 1994·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A CullM Stewart
Mar 30, 1995·International Journal of Radiation Oncology, Biology, Physics·C A Sklar, L S Constine
Mar 26, 1998·Brain, Behavior, and Immunity·J A OlschowkaJ T Hansen
Feb 3, 2000·International Journal of Radiation Oncology, Biology, Physics·C A MeyersW H Morrison
Dec 21, 2000·International Journal of Radiation Oncology, Biology, Physics·A C PaulinoB C Wen
Aug 31, 2001·Microscopy Research and Technique·P J Gebicke-Haerter
May 8, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Alexander H DalpkeKlaus Heeg
May 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Helga E de VriesTimo K van den Berg
Aug 17, 2002·Canadian Journal of Physiology and Pharmacology·Michel DiserboChristine Amourette
Nov 12, 2002·Medical and Pediatric Oncology·Tonny Solveig ReimersJørn Müller
Nov 14, 2002·Proceedings of the National Academy of Sciences of the United States of America·Jonathan KipnisMichal Schwartz
Nov 15, 2002·Journal of Neuropathology and Experimental Neurology·Malika BsibsiJohannes M van Noort
Nov 26, 2002·Journal of Neuroimmunology·Susanne A WolfRobert Nitsch
Nov 25, 2003·International Journal of Radiation Biology·E YinA J Wyrobek
Feb 7, 2004·Seminars in Oncology·Martin J B Taphoorn
Feb 11, 2004·Proceedings of the National Academy of Sciences of the United States of America·Eric M BlalockPhilip W Landfield
May 14, 2004·Proceedings of the National Academy of Sciences of the United States of America·Jonathan KipnisMichal Schwartz
Jan 8, 2005·Seminars in Neurology·Anthony Béhin, Jean-Yves Delattre
Jul 26, 2005·Trends in Immunology·Britta Engelhardt, Richard M Ransohoff
Oct 6, 2005·Neurobiology of Disease·So-Young HwangInn-Oc Han
Dec 31, 2005·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·J J M HoozemansP Eikelenboom
Mar 10, 2006·Pediatric Blood & Cancer·Tonny Solveig ReimersKjeld Schmiegelow
Jun 16, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jung-Bin KimJa-Kyeong Lee
Jul 10, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Richard A O'ConnorStephen M Anderton
Oct 24, 2007·Trends in Neurosciences·Knut BiberHendrikus W G M Boddeke
Nov 21, 2007·Nature Neuroscience·Bahareh AjamiFabio M V Rossi
Jan 1, 2008·International Journal of Radiation Oncology, Biology, Physics·Matthew K SchindlerDavid R Riddle

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Citations

Feb 20, 2019·International Journal of Molecular Sciences·Sudip BanerjeeSnehalata A Pawar
Jan 8, 2019·Neuro-oncology·Casmir TurnquistCurtis C Harris
Jul 14, 2020·International Journal of Radiation Biology·Kati KivisaariTapio Mappes
Jul 30, 2019·Frontiers in Neuroscience·Judith MetzdorfIngo Kleiter
Sep 22, 2020·Journal of Neuroinflammation·Lindsay A HohsfieldKim N Green
Mar 9, 2019·Annals of Clinical and Translational Neurology·Vanessa WiggermannAnthony L Traboulsee
Feb 11, 2020·Journal of Alzheimer's Disease : JAD·Kelly CeyzériatThomas Zilli
Jun 6, 2018·Frontiers in Aging Neuroscience·Neel K SharmaSanchita P Ghosh
Feb 20, 2020·Cellular and Molecular Life Sciences : CMLS·Ehsan KhodamoradiBagher Farhood
Oct 19, 2017·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Edilaine Honorio da SilvaNico Buls
Aug 7, 2019·Neuro-oncology Practice·Adrian BudhramMaria MacDonald
Mar 27, 2019·Environmental Science and Pollution Research International·Nadia Abdel-MagiedAmal G Ahmed
Apr 25, 2020·International Journal of Molecular Sciences·Yong Qin KohAlexandre Chan
Oct 11, 2020·International Journal of Molecular Sciences·Maria PeleliAndreas Papapetropoulos
Sep 19, 2020·International Journal of Radiation Biology·Eloise ParisetSylvain V Costes
Nov 17, 2020·Frontiers in Behavioral Neuroscience·Vipan K PariharCharles L Limoli
Dec 3, 2020·International Journal of Radiation Biology·Marie-Claire UngSabine M Hölter
Dec 12, 2020·International Journal of Radiation Oncology, Biology, Physics·Christine A BeamishM Waleed Gaber
Jan 29, 2021·Advanced Healthcare Materials·Jiani XieYuliang Zhao
Nov 7, 2020·Environmental Science and Pollution Research International·Nahed Abdel-AzizHelen N Saada
Mar 24, 2021·Neurochemical Research·Noura Magdy ThabetEnas Mahmoud Moustafa
Feb 3, 2020·Journal of the Neurological Sciences·Jigisha P ThakkarRimas V Lukas
Jun 15, 2021·Expert Opinion on Investigational Drugs·Rujapope SutiwisesakArthur E Warrington
Jun 16, 2021·International Journal of Radiation Biology·Marjan BoermaJacqueline P Williams
Jul 10, 2020·CNS & Neurological Disorders Drug Targets·Gautam KumarNitesh Kumar
Jul 20, 2021·International Journal of Radiation Oncology, Biology, Physics·Zoé SchmalClaudia E Rübe

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