Ionomycin-regulated phosphorylation of the myeloid calcium-binding protein p14.

Nature
J EdgeworthN Hogg

Abstract

Two associated calcium-binding proteins (CaBPs) have recently been identified specifically in cells of myeloid origin. These proteins have relative molecular masses (Mr) of 8,000 and 14,000 and are variously referred to as the cystic fibrosis antigen, the L1 light chain, MRP-8 or p8, and the L1 heavy chain, MRP14 or p14, respectively. The expression of p8 and p14 seems to be confined to a specific stage of myeloid cell differentiation, because both proteins are expressed in circulating neutrophils and monocytes but not in normal tissue macrophages. In chronic inflammatory conditions, however, such as rheumatoid arthritis, macrophages in affected tissues express both p8 and p14. These proteins are members of a family of CaBPs of low Mr, which include S-100 alpha and beta proteins, calcyclin (2A9), intestinal CaBP and p11. All the proteins have an Mr of approximately 10,000 with the exception of p14 which has a longer C-terminal sequence after the second calcium-binding domain. Little is known about their function, although by analogy with calmodulin they could be molecules involved in intracellular signalling that are activated by an increase in the intracellular Ca2+ concentration ([Ca2+]). Here we report that p14 is phosphoryl...Continue Reading

References

Mar 1, 1979·Analytical Biochemistry·R C Higgins, M E Dahmus
Jun 15, 1989·Nature·P FreemontJ Edgeworth
Jan 1, 1980·CRC Critical Reviews in Biochemistry·R H Kretsinger
May 1, 1981·European Journal of Biochemistry·T Isobe, T Okuyama
Jan 1, 1987·Immunology Today·T A Hamilton, D O Adams

❮ Previous
Next ❯

Citations

Apr 1, 1992·Molecular Reproduction and Development·J DingR M Moor
Sep 1, 1996·Histochemistry and Cell Biology·K DziegielewskaN R Saunders
Oct 11, 1996·Biochimica Et Biophysica Acta·C Geczy
Jan 1, 1995·Brain Research Bulletin·D B ZimmerW Song
Jan 1, 1996·The International Journal of Biochemistry & Cell Biology·E C Dell'AngelicaJ A Santome
Nov 14, 1997·Clinica Chimica Acta; International Journal of Clinical Chemistry·J StulíkP Jungblut
Nov 26, 2009·Immunology and Cell Biology·Chandima PereraCarolyn L Geczy
Apr 30, 2011·Molecular BioSystems·Sergei E PermyakovEugene A Permyakov
Jan 6, 2009·The Journal of Biological Chemistry·Chantrakorn ChampaiboonMark C Herzberg
Jun 30, 2010·Molecular & Cellular Proteomics : MCP·Tiziana CabrasIrene Messana
Jan 1, 1992·The Journal of Cell Biology·I DransfieldN Hogg
Feb 7, 2007·The Journal of Experimental Medicine·Atta BehfarAndre Terzic
Nov 1, 1995·Scandinavian Journal of Immunology·P A Clohessy, B E Golden
Oct 1, 1996·European Journal of Biochemistry·F GuignardM Markert
Jun 4, 2008·Journal of Leukocyte Biology·Sabrina Bréchard, Eric J Tschirhart
Oct 27, 2010·PloS One·Mark C DessingJaklien C Leemans
Apr 11, 2012·International Journal of Molecular Sciences·Thomas VoglLudmilla A Morozova-Roche
Dec 28, 2012·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Christoph KesselDirk Foell
Dec 5, 2014·Scandinavian Journal of Clinical and Laboratory Investigation·Pelin OktayogluKemal Nas
Dec 14, 2004·Arthritis and Rheumatism·Dirk Foell, Johannes Roth
Mar 20, 2003·Microscopy Research and Technique·Wolfgang NackenClaus Kerkhoff
Aug 2, 2005·Journal of Biochemistry and Molecular Biology·Reza YousefiMojtaba Amani
Aug 7, 1998·Protein Expression and Purification·C van den BosJ Roth
Jan 27, 1999·Biochimica Et Biophysica Acta·C KerkhoffC Sorg
Sep 28, 2006·Arthritis Research & Therapy·James N JarvisMichael Centola
May 15, 2015·PloS One·Sanne Bøjet LarsenAnne-Mette Hvas
Jun 3, 2016·BMC Structural Biology·Haili LinLaure Yatime
Jul 19, 2006·Biochemical Pharmacology·Christoffer GebhardtJochen Hess

❮ Previous
Next ❯

Related Concepts

Related Feeds

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.